| Autor: |
Petelin DS; Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia., Bairamova SP; Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia., Akhapkin RV; Serbsky National Medical Research Center of Psychiatry and Narcology, Moscow, Russia., Kudryashov NV; Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.; Zakusov Institute of Pharmacology, Moscow, Russia., Sorokina OY; Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia., Semin SA; «Spasenie» Clinic, LLC, Moscow, Russia., Volel BA; Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.; Mental Health Research Center, Moscow, Russia. |
| Abstrakt: |
Despite the proven importance of neurosteroids in many physiological processes, their role in the pathogenesis of the most of psychiatric disorders remains relatively understudied. This article reviews the current clinical evidence on the effects of neurosteroids on the formation and treatment of anxiety disorder, depression, bipolar disorder, and schizophrenia. In particular, the article points out the ambivalent nature of the effects of neurosteroids on GABA A - and other receptors. We are especially interested in the anxiolytic and anxiogenic effects of some neurosteroids, the antidepressant effect of allopregnanolone in treating postpartum and other forms of depression, and the nature of short- and long-term mechanisms of antidepressant effects of neurosteroids of different types. The currently unproven hypothesis about the effect of changes in the level of neurosteroids on the course of bipolar disorder is also discussed, with an analysis of the scientific evidence on the development of schizophrenic symptomatology in relation to changing neurosteroid levels in the context of positive and cognitive symptoms. |
