The impact of membrane perforation and L-PRF for vertical ridge augmentation with a xenogeneic block graft: an experimental study in a canine model.

Autor: Eldabe AK; Dept. of Oral Medicine and Periodontology, Faculty of Dentistry, Assiut University, Assiut, Egypt., Abdel-Ghaffar KA; Dept. of Oral Medicine and Periodontology, Faculty of Dentistry, Ain Shams University, Cairo, Egypt., Amr AE; Dept. of Oral Medicine and Periodontology, Faculty of Dentistry, Ain Shams University, Cairo, Egypt., Abu-Seida AM; Dept. of Surgery, Anesthesiology, and Radiology, Faculty of Veterinary Medicine, Cairo University, Giza, PO: 12211, Egypt., Abdelhamid ES; Dept. of Oral Pathology, Faculty of Dentistry, Ain Shams University, Cairo, Egypt., Gamal AY; Ain Shams University, Faculty of Dentistry, Cairo, Egypt. hgamal1@hotmail.com.; Misr University for Science and Technology, Faculty of Dentistry, October 5 City, Egypt. hgamal1@hotmail.com.
Jazyk: angličtina
Zdroj: Clinical oral investigations [Clin Oral Investig] 2023 Jul; Vol. 27 (7), pp. 3949-3960. Date of Electronic Publication: 2023 Apr 21.
DOI: 10.1007/s00784-023-05018-x
Abstrakt: Objectives: This study evaluated clinically and histologically the efficacy of modified perforated collagen membrane (PCM) and/or leukocyte- and platelet-rich fibrin (L-PRF) in combination with xenogeneic block bone graft in the vertical alveolar ridge augmentation.
Materials and Methods: Six adult mongrel dogs were enrolled in this randomized blinded study. After defect preparation, xenogeneic screw-fixed block graft was covered by an occlusive collagen membrane in group 1 that represented the control group (Block + CM). In group 2, L-PRF membrane was added first before top coverage by occlusive collagen membrane (Block + L-PRF + CM). Groups 3 (Block + PCM) and 4 (Block + L-PRF + PCM) were identical to the first two groups except that the occlusive collagen membrane was replaced by a perforated one. Following a healing period of 2 months, the dogs were submitted to the surgical reentry phase for clinical and histological evaluation.
Results: Clinically, no significant differences were found among all groups regarding vertical and horizontal ridge dimensions (p = 0.155, 0.492, respectively). Histomorphometric analysis revealed that the percentage of the total bone area and mature bone was significantly higher in group 4 (69.36 ± 2.72, 33.11 ± 5.18) compared to the control group (59.17 ± 4.27, 21.94 ± 2.86) (p = 0. 027, p = 0.029).
Conclusion: The use of xenogenic block grafts in combination with a double-layered perforated collagen L-PRF membrane in vertical ridge augmentation appeared to improve the inductive power of this challenging defect type.
Clinical Relevance: Size and number of perforations may affect the mechanical and handling properties of the membrane.
(© 2023. The Author(s).)
Databáze: MEDLINE
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