Risk of cancer in patients with insomnia: Nationwide retrospective cohort study (2009-2018).

Autor: Yoon K; Department of Internal Medicine, Seonam Hospital, Seoul, South Korea., Shin CM; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea., Han K; Department of Statistics and Actuarial Science, Soongsil University, Seoul, South Korea., Jung JH; Department of Medical Statistics, College of Medicine, The Catholic University of Korea, Seoul, South Korea., Jin EH; Department of Internal Medicine, Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, South Korea., Lim JH; Department of Internal Medicine, Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, South Korea., Kang SJ; Department of Internal Medicine, Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, South Korea., Choi YJ; Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea., Lee DH; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2023 Apr 21; Vol. 18 (4), pp. e0284494. Date of Electronic Publication: 2023 Apr 21 (Print Publication: 2023).
DOI: 10.1371/journal.pone.0284494
Abstrakt: Purpose: To investigate the association between insomnia and the risk of various cancers using the Korean National Health Insurance Service database.
Materials and Methods: Patients who underwent a national health examination in 2009 were followed-up until 2018. Newly-diagnosed cancers were collected one year after the baseline. Insomnia was defined as having a diagnosis of F510 or G470 within one year prior to enrollment. The incidence of various cancers was compared between patients with and without insomnia.
Results: In the overall study population (N = 3,982,012), the risk for any type of cancer was not different between controls and insomnia patients (adjusted hazard ratio [aHR]: 0.990). However, it was different by age; insomnia increased the risk of any cancer in younger age groups (20-39y and 40-59y, aHR:1.310 and 1.139, respectively) but it significantly decreased the risk in the 60-79y age group (aHR: 0.939). In cancer type, colorectal cancer risk was lower (aHR: 0.872, P < 0.0001), whereas leukemia risk was higher (aHR: 1.402, P < 0.0001) in patients with insomnia than in those without it, regardless of sex. In men, the risk of stomach cancer was lower (aHR: 0.882, P = 0.0003), and the risks of lung (aHR:1.114, P = 0.0005), kidney (aHR 1.226, P = 0.0107), and prostate (aHR:1.101, P = 0.0028) cancers were higher in insomnia patients than in control patients. In women, insomnia patients compared to control patients showed a lower risk of ovarian cancer (aHR:0.856, P = 0.0344, respectively), while they had a higher risk of oral (aHR:1.616, P = 0.002), thyroid (aHR:1.072, P = 0.0192), and nerve (aHR: 1.251, P = 0.016) cancers.
Conclusion: Insomnia is associated with an increased or decreased risk of some cancers, depending on age, cancer type and sex.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Yoon et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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