Single-cell transcriptomics of a dynamic cell behavior in murine airways.

Autor:	Kwok SJJ; Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Cambridge, United States.; Harvard-MIT Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, United States., Montoro DT; Broad Institute of MIT and Harvard, Cambridge, United States.; Department of Systems Biology, Harvard Medical Schoo, Boston, United States., Haber AL; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, United States., Yun SH; Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Cambridge, United States.; Harvard-MIT Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, United States., Vinarsky V; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, United States.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Boston, United States.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2023 Apr 21; Vol. 12. Date of Electronic Publication: 2023 Apr 21.
DOI:	10.7554/eLife.76645
Abstrakt:	Despite advances in high-dimensional cellular analysis, the molecular profiling of dynamic behaviors of cells in their native environment remains a major challenge. We present a method that allows us to couple the physiological behaviors of cells in an intact murine tissue to deep molecular profiling of individual cells. This method enabled us to establish a novel molecular signature for a striking migratory cellular behavior following injury in murine airways. Competing Interests: SK Currently an employee of and has financial interests in LASE Innovation Inc, DM, AH No competing interests declared, SY Has financial interests in LASE Innovation Inc that were reviewed and are managed by Massachusetts General Hospital and Mass General Brigham in accordance with their conflict-of-interest policies, VV Currently an employee and has financial interest in Vertex Pharmaceuticals, Inc (© 2023, Kwok, Montoro, Haber et al.)
Databáze:	MEDLINE
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