Macrophages - Controlling the Bifurcation Between Tumor Existence or Regression.

Autor: Novobrantseva T; Research and Development, Verseau Therapeutics, Newton, MA, 02466, USA., Manfra D; Research and Development, Verseau Therapeutics, Newton, MA, 02466, USA., Nguyen A; Research and Development, Verseau Therapeutics, Newton, MA, 02466, USA., Feldman I; Research and Development, Verseau Therapeutics, Newton, MA, 02466, USA.
Jazyk: angličtina
Zdroj: Advanced biology [Adv Biol (Weinh)] 2023 Oct; Vol. 7 (10), pp. e2300047. Date of Electronic Publication: 2023 Apr 21.
DOI: 10.1002/adbi.202300047
Abstrakt: Macrophages are multifunctional cells that are employed by the tumor to further its growth and adaptation. While tumor-associated macrophages (TAMs) have widely diverse phenotypes, tumors coevolve with the ones that can promote tumorigenesis. Functionally, TAMs/myeloid cells constitute the largest negative influence on the tumor microenvironment and need to be reprogrammed in order to enable successful anti-tumor response in most tumors. It is predicted that successful TAM repolarization has the potential to become a staple of immuno-oncology across most indications.
(© 2023 Wiley-VCH GmbH.)
Databáze: MEDLINE
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