Shaping of the alveolar landscape by respiratory infections and long-term consequences for lung immunity.

Autor:	Rodriguez-Rodriguez L; Laboratory of Immunology and Vaccinology, Faculty of Veterinary Medicine, Fundamental and Applied Research for Animals & Health Research Unit (FARAH), ULiege, Liege, Belgium., Gillet L; Laboratory of Immunology and Vaccinology, Faculty of Veterinary Medicine, Fundamental and Applied Research for Animals & Health Research Unit (FARAH), ULiege, Liege, Belgium., Machiels B; Laboratory of Immunology and Vaccinology, Faculty of Veterinary Medicine, Fundamental and Applied Research for Animals & Health Research Unit (FARAH), ULiege, Liege, Belgium.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2023 Apr 04; Vol. 14, pp. 1149015. Date of Electronic Publication: 2023 Apr 04 (Print Publication: 2023).
DOI:	10.3389/fimmu.2023.1149015
Abstrakt:	Respiratory infections and especially viral infections, along with other extrinsic environmental factors, have been shown to profoundly affect macrophage populations in the lung. In particular, alveolar macrophages (AMs) are important sentinels during respiratory infections and their disappearance opens a niche for recruited monocytes (MOs) to differentiate into resident macrophages. Although this topic is still the focus of intense debate, the phenotype and function of AMs that recolonize the niche after an inflammatory insult, such as an infection, appear to be dictated in part by their origin, but also by local and/or systemic changes that may be imprinted at the epigenetic level. Phenotypic alterations following respiratory infections have the potential to shape lung immunity for the long-term, leading to beneficial responses such as protection against allergic airway inflammation or against other infections, but also to detrimental responses when associated with the development of immunopathologies. This review reports the persistence of virus-induced functional alterations in lung macrophages, and discusses the importance of this imprinting in explaining inter-individual and lifetime immune variation. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Rodriguez-Rodriguez, Gillet and Machiels.)
Databáze:	MEDLINE
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