HLA-B27 positivity in a large miscegenated population of 5,389,143 healthy blood marrow donors in Brazil.

Autor: Resende GG; Hospital das Clínicas - Universidade Federal de Minas Gerais (HC-UFMG), Al. Álvaro Celso 175 / 2º floor, Belo Horizonte, MG, Brasil. gustavogomesresende@yahoo.com.br., Saad CGS; Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil., de Oliveira DCM; Registro Brasileiro de Doadores Voluntários de Medula Óssea (REDOME), Instituto Nacional de Câncer (INCA), Rio de Janeiro, Brazil., de Sousa Bueno Filho JS; Departamento de Estatística, Universidade Federal de Lavras (UFLA), Lavras, Brazil., Sampaio-Barros PD; Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil., de Medeiros Pinheiro M; Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Advances in rheumatology (London, England) [Adv Rheumatol] 2023 Apr 20; Vol. 63 (1), pp. 16. Date of Electronic Publication: 2023 Apr 20.
DOI: 10.1186/s42358-023-00302-6
Abstrakt: Background: The prevalence of HLA-B27 gene positivity in healthy Caucasian communities varies between 8 and 14%. However, there is a lack of information in countries with a high rate of miscegenation, such as Brazil.
Aim: To estimate the frequency of HLA-B27 in the Brazilian general population using a large national registry database.
Methods: This is a cross-sectional ecological study using the Brazilian Registry of Volunteer Bone Marrow Donors (REDOME) database on HLA-B27 allelic frequency and proportion of positives of healthy donors (18-60 years old). Data were analyzed according to sex, age, race (by self-reported skin color recommended by the Brazilian Institute of Geography and Statistics - IBGE), and geographic region of residence.
Results: From 1994 to 2022, a total of 5,389,143 healthy bone marrow donors were included. The overall positivity for HLA-B27 was 4.35% (CI 95% 4.32-4.37%), regardless of sex and age (57.2% were women, mean age was 41.7yo). However, there was a difference between races: 4.85% in Whites; 2.92% in Blacks; 3.76% in Pardos (Browns i.e. mixed races); 3.95% in Amarelos (Yellows i.e. Asian Brazilians); and 3.18% in Indigenous. There was also a difference regarding geographic region of residence (North: 3.62%; Northeast: 3.63%; Southeast: 4.29%; Midwest: 4.5% and 5.25% in South). The homozygosity rate for the HLA-B27 was 1.32% of all the positives and only 0.06% in the general population.
Conclusions: Our findings provide the first Brazilian national prevalence for HLA-B27 in 4.35%. There is a gradient gene positivity from North to South, suggesting that the genetic background related to the miscegenation due to colonization, slavery, and some later waves of immigration together with internal migratory flows, could explain our findings.
(© 2023. The Author(s).)
Databáze: MEDLINE
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