White blood cell count profiles in anti-aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorder and anti-myelin oligodendrocyte glycoprotein antibody-associated disease.

Autor: Akaishi T; Department of Neurology, Tohoku University Graduate School of Medicine, Seiryo-Machi 1-1, Aoba-Ku, Sendai, Miyagi, 980-8574, Japan. t-akaishi@med.tohoku.ac.jp.; Department of Education and Support for Regional Medicine, Tohoku University Hospital, Sendai, Japan. t-akaishi@med.tohoku.ac.jp., Misu T; Department of Neurology, Tohoku University Graduate School of Medicine, Seiryo-Machi 1-1, Aoba-Ku, Sendai, Miyagi, 980-8574, Japan., Fujihara K; Department of Multiple Sclerosis Therapeutics, Fukushima Medical University, Fukushima, Japan., Nakaya K; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Nakaya N; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Nakamura T; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Kogure M; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Hatanaka R; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Itabashi F; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Kanno I; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Kaneko K; Department of Neurology, Tohoku University Graduate School of Medicine, Seiryo-Machi 1-1, Aoba-Ku, Sendai, Miyagi, 980-8574, Japan., Takahashi T; Department of Neurology, Tohoku University Graduate School of Medicine, Seiryo-Machi 1-1, Aoba-Ku, Sendai, Miyagi, 980-8574, Japan.; Department of Neurology, National Hospital Organization Yonezawa National Hospital, Yonezawa, Japan., Fujimori J; Department of Neurology, Tohoku Medical and Pharmaceutical University, Sendai, Japan., Takai Y; Department of Neurology, Tohoku University Graduate School of Medicine, Seiryo-Machi 1-1, Aoba-Ku, Sendai, Miyagi, 980-8574, Japan., Nishiyama S; Department of Neurology, Tohoku University Graduate School of Medicine, Seiryo-Machi 1-1, Aoba-Ku, Sendai, Miyagi, 980-8574, Japan., Ishii T; Department of Education and Support for Regional Medicine, Tohoku University Hospital, Sendai, Japan., Aoki M; Department of Neurology, Tohoku University Graduate School of Medicine, Seiryo-Machi 1-1, Aoba-Ku, Sendai, Miyagi, 980-8574, Japan., Nakashima I; Department of Neurology, Tohoku Medical and Pharmaceutical University, Sendai, Japan., Hozawa A; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Apr 20; Vol. 13 (1), pp. 6481. Date of Electronic Publication: 2023 Apr 20.
DOI: 10.1038/s41598-023-33827-3
Abstrakt: White blood cell (WBC) count profiles in anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4-NMOSD) and anti-myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are still unknown. This study evaluated the total WBC count, differential WBC counts, monocyte-to-lymphocyte ratio (MLR), and neutrophil-to-lymphocyte ratio (NLR) in patients with these diseases within three months from an attack before acute treatment or relapse prevention and compared the profiles with those in matched volunteers or in multiple sclerosis (MS) patients. AQP4-NMOSD patients (n = 13) had a higher neutrophil count (p = 0.0247), monocyte count (p = 0.0359), MLR (p = 0.0004), and NLR (p = 0.0037) and lower eosinophil (p = 0.0111) and basophil (p = 0.0283) counts than those of AQP4-NMOSD-matched volunteers (n = 65). Moreover, patients with MOGAD (n = 26) had a higher overall WBC count (p = 0.0001), neutrophil count (p < 0.0001), monocyte count (p = 0.0191), MLR (p = 0.0320), and NLR (p = 0.0002) than those of MOGAD-matched volunteers (n = 130). The three demyelinating diseases showed similar levels of the total and differential WBC counts; however, MOGAD and MS showed different structures in the hierarchical clustering and distributions on a two-dimensional canonical plot using differential WBC counts from the other three groups. WBC count profiles were similar in patients with MOGAD and MS but differed from profiles in matched volunteers or patients with AQP4-NMOSD.
(© 2023. The Author(s).)
Databáze: MEDLINE
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