Pathogenetic Mechanisms of Mental Disorders: Endogenous Intoxication.

Autor:	Uzbekov MG; Moscow Research Institute of Psychiatry, Serbsky National Research Center of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, 107258, Russia. uzbekovmg@gmail.com.
Jazyk:	angličtina
Zdroj:	Biochemistry. Biokhimiia [Biochemistry (Mosc)] 2023 Apr; Vol. 88 (4), pp. 491-501.
DOI:	10.1134/S0006297923040053
Abstrakt:	The review describes the syndrome of endogenous intoxication in patients with mental disorders. Oxidative stress, middle-mass endotoxic molecules, impaired functional properties of serum albumin and albumin thiol groups, neurotrophic factors, and enzymes, including monoamine oxidase and semicarbazide-sensitive amine oxidase contribute to the development of endogenous intoxication. Possible pathogenetic mechanisms of the endogenous intoxication development in mental disorders and approaches to its treatment are discussed.
Databáze:	MEDLINE
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