The impact of the COVID-19 lockdown on birthweight among singleton term birth in Denmark.

Autor: de Knegt VE; Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.; Department of Paediatrics, Copenhagen University Hospital Slagelse, Slagelse, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Hedley PL; Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.; Brazen Bio, Los Angeles, California, United States of America., Hedermann G; Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.; Department of Obstetrics and Gynaecology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Wilstrup C; Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.; Abzu, Copenhagen, Denmark., Bækvad-Hansen M; Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.; Danish Center for Neonatal Screening, Statens Serum Institut, Copenhagen, Denmark., Thagaard IN; Department of Obstetrics and Gynaecology, Copenhagen University Hospital Slagelse, Slagelse, Denmark., Hjalgrim H; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.; Department of Haematology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.; Danish Cancer Society Research Center, Copenhagen, Denmark., Kanters J; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark., Melbye M; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Danish Cancer Society Research Center, Copenhagen, Denmark.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States of America., Hougaard DM; Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.; Danish Center for Neonatal Screening, Statens Serum Institut, Copenhagen, Denmark., Hviid A; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.; Pharmacovigilance Research Center, Department of Drug Development and Clinical Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Krebs L; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Obstetrics and Gynaecology, Copenhagen University Hospital, Amager and Hvidovre Hospital, Copenhagen, Denmark., Breindahl M; Department of Neonatology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark., Lausten-Thomsen U; Department of Neonatology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark., Christiansen M; Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2023 Apr 20; Vol. 18 (4), pp. e0283909. Date of Electronic Publication: 2023 Apr 20 (Print Publication: 2023).
DOI: 10.1371/journal.pone.0283909
Abstrakt: In Denmark, a nationwide COVID-19 lockdown was implemented on March 12, 2020 and eased on April 14, 2020. The COVID-19 lockdown featured reduced prevalence of extremely preterm or extremely low birthweight births. This study aims to explore the impact of this COVID-19 lockdown on term birthweights in Denmark. We conducted a nationwide register-based cohort study on 27,870 live singleton infants, born at term (weeks 37-41), between March 12 and April 14, 2015-2020, using data from the Danish Neonatal Screening Biobank. Primary outcomes, corrected for confounders, were birthweight, small-for-gestational-age (SGA), and large-for-gestational-age (LGA), comparing the COVID-19 lockdown to the previous five years. Data were analysed using linear regression to assess associations with birthweight. Multinomial logistic regression was used to assess associations with relative-size-for-gestational-age (xGA) categories. Adjusted mean birthweight was significantly increased by 16.9 g (95% CI = 4.1-31.3) during the lockdown period. A dip in mean birthweight was found in gestational weeks 37 and 38 balanced by an increase in weeks 40 and 41. The 2020 lockdown period was associated with an increased LGA prevalence (aOR 1.13, 95% CI = 1.05-1.21). No significant changes in proportions of xGA groups were found between 2015 and 2019. The nationwide COVID-19 lockdown resulted in a small but significant increase in birthweight and proportion of LGA infants, driven by an increase in birthweight in gestational weeks 40 and 41.
Competing Interests: Dr Breindahl has a patent (NeoHelp) with royalties paid. Dr Breindahl has nothing else to disclose. All other authors have nothing else to disclose. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
(Copyright: © 2023 de Knegt et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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