The Alteration of Akkermansiaceae/Lachnospiraceae Ratio Is a Microbial Feature of Antibiotic-Induced Microbiota Remodeling.
| Autor: | Chen PC; Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan., Lin MS; Division of Pulmonary and Critical Care Medicine, Chia-Yi Christian Hospital, Chiayi., Lin TC; Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan., Kang TW; Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan., Ruan JW; Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan. |
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| Jazyk: | angličtina |
| Zdroj: | Bioinformatics and biology insights [Bioinform Biol Insights] 2023 Apr 14; Vol. 17, pp. 11779322231166229. Date of Electronic Publication: 2023 Apr 14 (Print Publication: 2023). |
| DOI: | 10.1177/11779322231166229 |
| Abstrakt: | Antibiotic treatment has been shown to cause gut microbiota dysbiosis. However, lacking critical features defining gut microbiota dysbiosis makes it challenging to prevent. By co-occurrence network analysis, we found that despite short antibiotic courses eliminating certain microbial taxa, the Akkermansia genus played the role of a high-centrality hub to maintain microbiota homeostasis. When the antibiotic courses continued, the elimination of Akkermansia induced a significant microbiota remodeling of the gut microbiota networks. Based on this finding, we found that under long-term antibiotic stress, the gut microbiota was rearranged into a stable network with a significantly lower Akkermansiaceae / Lachnospiraceae (A/L) ratio and no microbial hub. By functional prediction analysis, we confirmed that the gut microbiota with a low A/L ratio also had enhanced mobile elements and biofilm-formation functions that may be associated with antibiotic resistance. This study identified A/L ratio as an indicator of antibiotic-induced dysbiosis. This work reveals that besides the abundance of specific probiotics, the hierarchical structure also critically impacts the microbiome function. Co-occurrence analysis may help better monitor the microbiome dynamics than only comparing the differentially abundant bacteria between samples. Competing Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. (© The Author(s) 2023.) |
| Databáze: | MEDLINE |
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