Identification of gametocyte-associated pir genes in the rodent malaria parasite, Plasmodium chabaudi chabaudi AS.

Autor: Cunningham DA; The Francis Crick Institute, London, UK. Deirdre.Cunningham@crick.ac.uk., Reid AJ; Wellcome Sanger Institute, Cambridge, UK.; Wellcome/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, CB2 1QN, UK., Hosking C; The Francis Crick Institute, London, UK., Deroost K; The Francis Crick Institute, London, UK., Tumwine-Downey I; The Francis Crick Institute, London, UK., Sanders M; Wellcome Sanger Institute, Cambridge, UK., Langhorne J; The Francis Crick Institute, London, UK.
Jazyk: angličtina
Zdroj: BMC research notes [BMC Res Notes] 2023 Apr 19; Vol. 16 (1), pp. 56. Date of Electronic Publication: 2023 Apr 19.
DOI: 10.1186/s13104-023-06322-1
Abstrakt: Objective: To analyse the transcriptional profiles of the pir multigene family of Plasmodium chabaudi chabaudi in male and female gametocytes isolated from the blood of infected mice.
Results: Infected red blood cells containing female and male P. chabaudi gametocytes transcribe a distinct set of genes encoded by the multigene family pir. The overall patterns are similar to what has been observed in the close relative P. berghei, but here we show that gametocyte-associated pir genes are distinct from those involved in chronic blood-stage infection and highlight a male-associated pir gene which should be the focus of future studies.
(© 2023. The Author(s).)
Databáze: MEDLINE
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