Circumventing the Gastrointestinal Barrier for Oral Delivery of Therapeutic Proteins and Peptides (PPTS): Current Trends and Future Trajectories.

Autor:	Hashim LE; Department of Pharmaceutics, Department of Pharmacology and Pharmaceutical Chemistry, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM) Cawangan Selangor, 42300, Bandar Puncak Alam, Selangor, Malaysia., Sabri AH; School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, UK., Mohamad MA; Department of Gastrointestinal, Mater Hospital, Belfast Health and Social Trust, United Kingdom., Anjani QK; School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, UK.; Fakultas Farmasi, Universitas Megarezky, Jl., Makassar, 90234, Indonesia., Mustaffa MF; Department of Pharmaceutics, Department of Pharmacology and Pharmaceutical Chemistry, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM) Cawangan Selangor, 42300, Bandar Puncak Alam, Selangor, Malaysia., Abdul Hamid K; Department of Pharmaceutics, Department of Pharmacology and Pharmaceutical Chemistry, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM) Cawangan Selangor, 42300, Bandar Puncak Alam, Selangor, Malaysia.; Department of Pharmaceutics, Atta-ur-Rahman Institute for Natural Products Discovery (AuRIns), UiTM Cawangan Selangor, 42300, Bandar Puncak Alam, Selangor, Malaysia.
Jazyk:	angličtina
Zdroj:	Current drug delivery [Curr Drug Deliv] 2024; Vol. 21 (2), pp. 211-235.
DOI:	10.2174/1567201820666230418091506
Abstrakt:	Therapeutic proteins and peptides (PPTs) have become one of the most important biological molecules for the management of many common and complex diseases due to their high specificity and high bioactivity. However, these biomolecules are mainly given by the hypodermic injection, which often leads to poor patient compliance due to the invasive nature of this route of administration. The oral route has been considered the most convenient and patient-friendly route for drug delivery relative to hypodermic injections. Despite the ease and simplicity conferred by oral administration, this drug delivery route suffers rapid peptide degradation in gastric fluid and low intestinal uptake. In order to circumvent these issues, several strategies, such as enzyme inhibitors, permeation enhancers, chemical modification, mucoadhesive and stimuli-responsive polymers, and specialised particulate formulation have been developed. Such strategies are designed with the aim of protecting PPTs from the harsh gastrointestinal environment as well as providing a strategy to enhance the uptake of the therapeutic across the gastrointestinal tract. This review aims to provide an overview of the current development in enteral drug delivery strategies for PPTs. The design of these drug delivery systems in overcoming physical and chemical barriers along the gastrointestinal tract while improving oral bioavailability will be highlighted and discussed. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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