Report of Weil's disease with a fatal course triggered by Jarisch-Herxheimer reaction.

Autor: Chiko Y; Department of General Medicine, Okinawa Prefectural Yaeyama Hospital, Ishigaki, Japan. Electronic address: chikoyukiiiii@gmail.com., Shiokawa K; Department of General Medicine, Okinawa Prefectural Yaeyama Hospital, Ishigaki, Japan., Namihira I; Department of General Medicine, Okinawa Prefectural Yaeyama Hospital, Ishigaki, Japan., Itagaki K; Department of General Medicine, Okinawa Prefectural Yaeyama Hospital, Ishigaki, Japan., Maruyama K; Department of General Medicine, Okinawa Prefectural Yaeyama Hospital, Ishigaki, Japan., Tachibana Y; Department of General Medicine, Okinawa Prefectural Yaeyama Hospital, Ishigaki, Japan., Ryu Y; Department of General Medicine, Okinawa Prefectural Yaeyama Hospital, Ishigaki, Japan., Sakai T; Department of General Medicine, Okinawa Prefectural Yaeyama Hospital, Ishigaki, Japan.
Jazyk: angličtina
Zdroj: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy [J Infect Chemother] 2023 Aug; Vol. 29 (8), pp. 800-802. Date of Electronic Publication: 2023 Apr 17.
DOI: 10.1016/j.jiac.2023.04.009
Abstrakt: Leptospirosis, a zoonotic disease characterized by a spectrum of influenza-like symptoms, can manifest as severe cases so called Weil's disease. Early diagnosis and treatment are crucial to avoid the potentially fatal course of the disease. Within 24 hours of the initial administration of antibiotics, patients may experience the Jarisch-Herxheimer reaction (JHR), characterized by chills, fever, hypotension, and impaired consciousness. The Okinawa Prefecture, where our hospital is situated, boasts the highest incidence rate of leptospirosis among all regions in Japan. This reports our encounter with the initial leptospirosis case after a period of 16 years within the Okinawa Prefecture. This case exhibited JHR and required the utilization of noradrenaline (NA). Despite evidence indicating that JHR does not correlate with mortality, we contend that diagnosis of Weil's disease necessitates admission to an intensive care unit (ICU) and vigilant monitoring for JHR, as it may result in impairment of general condition and fatal outcome, as observed in our case.
Competing Interests: Declaration of competing interest The authors state that they have no Conflict of Interest.
(Copyright © 2023 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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