Serum chromogranin A levels are associated with the SYNTAX score in coronary artery disease.

Autor:	Çelikkol A; Tekirdağ Namık Kemal Üniversitesi, Faculty of Medicine, Department of Medical Biochemistry - Tekirdağ, Turkey., Demirkıran A; Tekirdağ Namık Kemal Üniversitesi, Faculty of Medicine, Department of Cardiology - Tekirdağ, Turkey., Aydın C; Tekirdağ Namık Kemal Üniversitesi, Faculty of Medicine, Department of Cardiology - Tekirdağ, Turkey., Akyüz A; Tekirdağ Namık Kemal Üniversitesi, Faculty of Medicine, Department of Cardiology - Tekirdağ, Turkey., Kaplangöray M; University of Health Sciences, Mehmet Akif İnan Research and Training Hospital, Department of Cardiology - Şanlıurfa, Turkey., Yılmaz A; Tekirdağ Namık Kemal Üniversitesi, Faculty of Medicine, Department of Medical Biochemistry - Tekirdağ, Turkey., Efe MM; Tekirdağ Namık Kemal Üniversitesi, Faculty of Medicine, Department of Cardiology - Tekirdağ, Turkey., Güzel S; Tekirdağ Namık Kemal Üniversitesi, Faculty of Medicine, Department of Medical Biochemistry - Tekirdağ, Turkey.
Jazyk:	angličtina
Zdroj:	Revista da Associacao Medica Brasileira (1992) [Rev Assoc Med Bras (1992)] 2023 Apr 14; Vol. 69 (4), pp. e20221254. Date of Electronic Publication: 2023 Apr 14 (Print Publication: 2023).
DOI:	10.1590/1806-9282.20221254
Abstrakt:	Objective: In this article, we investigated the association of chromogranin A with coronary artery disease. Methods: Biochemical parameters and chromogranin A levels obtained from peripheral blood samples during coronary angiography were analyzed in 90 patients. Patients were classified into two groups, namely, SYNergy between PCI with TAXUS and Cardiac Surgery score ≥1 (n=45) and SYNergy between PCI with TAXUS and Cardiac Surgery score=0 (n=45). This is a cross-sectional, prospective study. Results: Serum chromogranin A levels were significantly higher in the group with SYNergy between PCI with TAXUS and Cardiac Surgery score ≥1 compared to the group with SYNergy between PCI with TAXUS and Cardiac Surgery score=0 (1381.5±418.9 ng/mL and 1121.2±290.7 ng/mL, respectively; p=0.002). Serum chromogranin A levels were correlated with SYNergy between PCI with TAXUS and Cardiac Surgery score (r=0.556, p<0.04). ROC analysis showed that the area under the curve for serum chromogranin A levels was 0.687 (p=0.007), and the best cutoff value of 1,131 ng/mL had a sensitivity of 67% and a specificity of 65% for the prediction of coronary artery disease. Conclusion: Serum chromogranin A levels were increased in coronary artery disease patients with SYNergy between PCI with TAXUS and Cardiac Surgery score ≥1. Increasing serum chromogranin A levels are proportional to the SYNergy between PCI with TAXUS and Cardiac Surgery score.
Databáze:	MEDLINE
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