Role of the Renin-Angiotensin System Components in Renal Cell Carcinoma: A Literature Review.

Autor: Mourão TC; Department of Urology, Fundação Antônio Prudente, A.C. Camargo Cancer Center, São Paulo, Brazil. thiago.mourao@accamargo.org.br., Bezerra SM; Department of Pathological Anatomy, Fundação Antônio Prudente, A.C. Camargo Cancer Center, Rua Prof. Antônio Prudente, São Paulo, 211, Brazil., Santos VE; Department of Urology, Fundação Antônio Prudente, A.C. Camargo Cancer Center, São Paulo, Brazil., Brazão ES Jr; Department of Urology, Fundação Antônio Prudente, A.C. Camargo Cancer Center, São Paulo, Brazil., da Costa WH; Department of Urology, Fundação Antônio Prudente, A.C. Camargo Cancer Center, São Paulo, Brazil.; National Institute for Science and Technology in Oncogenomics and Therapeutic Innovation, São Paulo, Brazil., Zequi SC; Department of Urology, Fundação Antônio Prudente, A.C. Camargo Cancer Center, São Paulo, Brazil.; National Institute for Science and Technology in Oncogenomics and Therapeutic Innovation, São Paulo, Brazil.; Graduate School, Department of Surgery, Division of Urology, São Paulo Federal University, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Current urology reports [Curr Urol Rep] 2023 Jul; Vol. 24 (7), pp. 345-353. Date of Electronic Publication: 2023 Apr 19.
DOI: 10.1007/s11934-023-01160-x
Abstrakt: Purpose of Review: The physiological aspects of renin-angiotensin system (RAS) components are described in this review. Additionally, we present the main results of studies that could indicate an association between alterations in these components and cancer, particularly renal cell carcinoma (RCC).
Recent Findings: The RAS undergoes a series of homeostatic and modulatory processes that extend to hypertrophy, hyperplasia, fibrosis, and remodeling, as well as angiogenesis, pro-inflammatory responses, cell differentiation, stem cell programming, and hematopoiesis. The link between cancer-related inflammation and RAS signaling converge in the response to tumor hypoxia and oxidative stress mechanisms, particularly with the angiotensin type 1 receptor leading to activation of transcription factors such as nuclear factor κB (NF-κB), as well as members of the signal transducer and activation of transcription (STAT) family and HIF1⍺. Dysregulation of the physiological actions of RAS in the microenvironment of inflammation and angiogenesis promotes tumor cell growth.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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