The Incorporation of Curcuminoids in Gamma-Cyclodextrins Improves Their Poor Bioaccessibility, Which Is due to Both Their Very Low Incorporation into Mixed Micelles and Their Partial Adsorption on Food.

Autor: Borel P; C2VN, Aix Marseille Univ, INRAE, INSERM, Marseille, 13005, France., Hammaz F; C2VN, Aix Marseille Univ, INRAE, INSERM, Marseille, 13005, France., Lecourt L; C2VN, Aix Marseille Univ, INRAE, INSERM, Marseille, 13005, France., Marconot G; C2VN, Aix Marseille Univ, INRAE, INSERM, Marseille, 13005, France., Gillet G; C2VN, Aix Marseille Univ, INRAE, INSERM, Marseille, 13005, France., Rozier C; ID4Feed, Annecy, 74000, France., Desmarchelier C; C2VN, Aix Marseille Univ, INRAE, INSERM, Marseille, 13005, France.; Institut Universitaire de France (IUF), Paris, 75231, France.
Jazyk: angličtina
Zdroj: Molecular nutrition & food research [Mol Nutr Food Res] 2023 Jun; Vol. 67 (12), pp. e2200798. Date of Electronic Publication: 2023 May 01.
DOI: 10.1002/mnfr.202200798
Abstrakt: Scope: Turmeric curcuminoids mainly consist of curcumin (CUR), demethoxycurcumin (dCUR), and bisdemethoxycurcumin (bdCUR). CUR displays low bioavailability, partly due to poor solubilization in the intestinal lumen during digestion, while data for dCUR and bdCUR are scarce. The study aims to investigate the bioaccessibility of curcuminoids from turmeric extracts or from gamma-cyclodextrins, considering potential interactions with food.
Methods and Results: Using an in vitro digestion model (correlation with CUR bioavailability: r = 0.99), the study shows that curcuminoid bioaccessibility from turmeric extract without food is low: bdCUR (11.5 ± 0.6%) > dCUR (1.8 ± 0.1%) > CUR (0.8 ± 0.1%). Curcuminoids incorporated into gamma-cyclodextrins display higher bioaccessibilities (bdCUR: 21.1 ± 1.6%; dCUR: 14.3 ± 0.9%; CUR: 11.9 ± 0.7%). Curcuminoid bioaccessibility is highest without food (turmeric extract: 2.0 ± 0.1%; gamma-cyclodextrins: 12.4 ± 0.8%) and decreases with a meat- and potato-based meal (turmeric extract: 1.1 ± 0.2%; gamma-cyclodextrins: 2.4 ± 0.3%) or a wheat-based meal (turmeric extract: 0.1 ± 0.0%; gamma-cyclodextrins: 0.3 ± 0.1%). Curcuminoids exhibit low (<10%) incorporation efficiencies into synthetic mixed micelles (bdCUR > dCUR > CUR).
Conclusions: bdCUR and dCUR show greater bioaccessibilities versus CUR. Food diminishes curcuminoid bioaccessibility, likely by adsorption mechanisms. Gamma-cyclodextrins improve curcuminoid bioaccessibility.
(© 2023 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH.)
Databáze: MEDLINE
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