Pilot imaging of the colony stimulating factor 1 receptor in the brains of virally-suppressed individuals with HIV.

Autor:	Rubin LH; Department of Neurology.; Department of Psychiatry and Behavioral Sciences.; Department of Epidemiology.; Molecular and Comparative Pathobiology., Du Y; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD., Sweeney SE; Department of Psychiatry and Behavioral Sciences., O'Toole R; Department of Psychiatry and Behavioral Sciences., Harrington CK; Department of Psychiatry and Behavioral Sciences., Jenkins K; Department of Psychiatry and Behavioral Sciences., Lesniak WG; Department of Epidemiology., Veenhuis RT; Department of Neurology.; Molecular and Comparative Pathobiology., Dastgheyb R; Department of Neurology., Severson J; Clinical Ink, Inc., Horsham, PA, USA., Fan H; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD., Holt DP; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD., Hall AW; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD., Dannals RF; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD., Horti AG; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD., Pomper MG; Department of Psychiatry and Behavioral Sciences.; Molecular and Comparative Pathobiology.; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD., Coughlin JM; Department of Neurology.; Department of Psychiatry and Behavioral Sciences.
Jazyk:	angličtina
Zdroj:	AIDS (London, England) [AIDS] 2023 Jul 15; Vol. 37 (9), pp. 1419-1424. Date of Electronic Publication: 2023 Apr 05.
DOI:	10.1097/QAD.0000000000003572
Abstrakt:	Objective: Neuroimmune activation is a putative driver of cognitive impairment in people with HIV (PWH), even in the age of modern antiretroviral therapy. Nevertheless, imaging of the microglial marker, the 18 kDa translocator protein (TSPO), with positron emission tomography (PET) in treated PWH has yielded inconclusive findings. One potential reason for the varied TSPO results is a lack of cell-type specificity of the TSPO target. Design: [ 11 C]CPPC, 5-cyano- N -(4-(4-[ 11 C]methylpiperazin-1-yl)-2-(piperidin-1-yl)phenyl) furan-2-carboxaminde, is a radiotracer for use with PET to image the colony stimulating factor 1 receptor (CSF1R). The CSF1R is expressed on microglia and central nervous system macrophages, with little expression on other cell types. We used [ 11 C]CPPC PET in virally-suppressed- (VS)-PWH and HIV-uninfected individuals to estimate the effect sizes of higher CSF1R in the brains of VS-PWH. Methods: Sixteen VS-PWH and 15 HIV-uninfected individuals completed [ 11 C]CPPC PET. [ 11 C]CPPC binding (V T ) in nine regions was estimated using a one-tissue compartmental model with a metabolite-corrected arterial input function, and compared between groups. Results: Regional [ 11 C]CPPC V T did not significantly differ between groups after age- and sex- adjustment [unstandardized beta coefficient ( B ) = 1.84, standard error (SE) = 1.18, P  = 0.13]. The effect size was moderate [Cohen's d  = 0.56, 95% confidence interval (CI) -0.16, 1.28), with strongest trend of higher V T in VS-PWH in striatum and parietal cortex (each P  = 0.04; Cohen's d  = 0.71 and 0.72, respectively). Conclusions: A group difference in [ 11 C]CPPC V T was not observed between VS-PWH and HIV-uninfected individuals in this pilot, although the observed effect sizes suggest the study was underpowered to detect regional group differences in binding. (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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