Expert Consensus on the Use of On -Demand Treatments for OFF Episodes in Parkinson's Disease: A Modified Delphi Panel.

Autor: Isaacson SH; Parkinson's Disease and Movement Disorders Center of Boca Raton Boca Raton Florida USA., Achari M; Integrated Neurology PA, Department of Physical Medicine and Rehabilitation McGovern Medical School, University of Texas Houston Texas USA., Bhidayasiri R; Chulalongkorn Centre of Excellence for Parkinson's Disease and Related Disorders, Department of Medicine, Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society Bangkok Thailand.; The Academy of Science The Royal Society of Thailand Bangkok Thailand., Comella C; Department of Neurosurgery and Neurological Sciences Rush University Medical Center Chicago Illinois USA., Farmer JG; Global Neuroscience Institute Pennington New Jersey USA.; Department of Neurology Drexel College of Medicine Philadelphia Pennsylvania USA., Gupta F; Department of Neurology, Mount Sinai Medical Center Mount Sinai Beth Israel Morningside, Sinai West, The Mount Sinai Hospital New York City New York USA., Jones S; Parkinson and Movement Disorder Alliance Tucson Arizona USA., Kreitzman D; Parkinson's Disease and Movement Disorders Center of Long Island Commack New York USA., Kremens D; Department of Neurology Sidney Kimmel Medical College at Jefferson University Philadelphia Pennsylvania USA., Lewis SJG; Brain and Mind Center, School of Medical Sciences University of Sydney Sydney New South Wales Australia., Poewe W; Department of Neurology Medical University of Innsbruck Innsbruck Austria., Tolosa E; Parkinson's Disease Research Program University of Barcelona Barcelona Spain., Campos C; PHAR Beverly Hills California USA., Gibbs SN; PHAR Beverly Hills California USA., Broder MS; PHAR Beverly Hills California USA.
Jazyk: angličtina
Zdroj: Movement disorders clinical practice [Mov Disord Clin Pract] 2023 Mar 11; Vol. 10 (4), pp. 652-657. Date of Electronic Publication: 2023 Mar 11 (Print Publication: 2023).
DOI: 10.1002/mdc3.13690
Abstrakt: Background: On-demand treatments can treat OFF episodes in Parkinson's disease, however, there is limited information regarding when to prescribe them.
Objective: Develop expert consensus to determine appropriate clinical factors for considering on-demand treatments.
Methods: Using a RAND/UCLA modified Delphi panel method, a panel developed consensus on the use of on-demand treatments for OFF episodes.
Results: The panel agreed on-demand treatments were appropriate when OFF episodes were associated with greater functional impact and interfered with basic daily activities. The panel also agreed on-demand treatment may be appropriate for patients with morning akinesia and/or delayed ON of first levodopa dose and >1 type of OFF episode (eg, early morning OFF or wearing OFF regardless of frequency).
Conclusions: Experts agreed on-demand treatment is appropriate for many patients with OFF episodes. The greater the functional impact of OFF episodes, the more likely experts agreed that on-demand treatment is appropriate to prescribe.
(© 2023 Sunovion Pharmaceuticals Inc. Movement Disorders Clinical Practice published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.)
Databáze: MEDLINE
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