Factors associated with COVID-19 vaccination during June-October 2021: A multi-site prospective study.

Autor: Datar RS; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA., Fette LM; The Biostatistics Center, George Washington University, Rockville, MD, USA., Hinkelman AN; Jerry M. Wallace School of Osteopathic Medicine, Campbell University, Lillington, NC, USA., Hammershaimb EA; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA., Friedman-Klabanoff DJ; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA., Mongraw-Chaffin M; Department of Epidemiology & Prevention, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Weintraub WS; MedStar Health Research Institute, Georgetown University, Washington, DC, USA., Ahmed N; Center for Health Equity Research, MedStar Health Research Institute, Hyattsville, MD, USA., Gibbs MA; Atrium Health, Charlotte, NC, USA., Runyon MS; Atrium Health, Charlotte, NC, USA., Plumb ID; Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA., Thompson W; Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA., Saydah S; Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA., Edelstein SL; The Biostatistics Center, George Washington University, Rockville, MD, USA., Berry AA; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: aberry@som.umaryland.edu.
Jazyk: angličtina
Zdroj: Vaccine [Vaccine] 2023 May 11; Vol. 41 (20), pp. 3204-3214. Date of Electronic Publication: 2023 Mar 31.
DOI: 10.1016/j.vaccine.2023.03.057
Abstrakt: Introduction: Vaccine hesitancy presents a challenge to COVID-19 control efforts. To identify beliefs associated with delayed vaccine uptake, we developed and implemented a vaccine hesitancy survey for the COVID-19 Community Research Partnership.
Methods: In June 2021, we assessed attitudes and beliefs associated with COVID-19 vaccination using an online survey. Self-reported vaccination data were requested daily through October 2021. We compared responses between vaccinated and unvaccinated respondents using absolute standardized mean differences (ASMD). We assessed validity and reliability using exploratory factor analysis and identified latent factors associated with a subset of survey items. Cox proportional hazards models and mediation analyses assessed predictors of subsequent vaccination among those initially unvaccinated.
Results: In June 2021, 29,522 vaccinated and 1,272 unvaccinated participants completed surveys. Among those unvaccinated in June 2021, 559 (43.9 %) became vaccinated by October 31, 2021. In June, unvaccinated participants were less likely to feel "very concerned" about getting COVID-19 than vaccinated participants (10.6 % vs. 43.3 %, ASMD 0.792). Among those initially unvaccinated, greater intent to become vaccinated was associated with getting vaccinated and shorter time to vaccination. However, even among participants who reported no intention to become vaccinated, 28.5 % reported vaccination before study end. Two latent factors predicted subsequent vaccination-being 'more receptive' was derived from motivation to protect one's own or others' health and resume usual activities; being 'less receptive' was derived from concerns about COVID-19 vaccines. In a Cox model, both factors were partially mediated by vaccination intention.
Conclusion: This study characterizes vaccine hesitant individuals and identifies predictors of eventual COVID-19 vaccination through October 31, 2021. Even individuals with no intention to be vaccinated can shift to vaccine uptake. Our data suggest factors of perceived severity of COVID-19 disease, vaccine safety, and trust in the vaccine development process are predictive of vaccination and may be important opportunities for ongoing interventions.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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