| Autor: |
Elkolli M; Laboratoire de Microbiologie Appliquée, Faculté des Sciences de la Nature et de la Vie, Setif, Algeria., Elkolli H; Laboratoire des Matériaux Polymériques Multiphasiques, Département de Génie des Procédés, Faculté de Technologie, Sétif, Algeria., Alam M; Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia., Benguerba Y; Laboratoire de Biopharmacie et Pharmacotechnie (LPBT), Ferhat Abbas Setif 1 University, Setif, Algeria. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2024 Feb-Mar; Vol. 42 (3), pp. 1404-1416. Date of Electronic Publication: 2023 Apr 17. |
| DOI: |
10.1080/07391102.2023.2199865 |
| Abstrakt: |
The misuse and overuse of antibiotics have resulted in antibiotic resistance. However, there are alternative approaches that could either substitute antibiotics or enhance their effectiveness without harmful side effects. One such approach is the use of terpene-rich essential oils. In this study, we aimed to demonstrate the antibacterial activity of the main components of three plant essential oils, namely Anthemis punctata , Anthemis pedunculata and Daucus crinitus . Specifically, we targeted bacterial tyrosyl-tRNA synthetase, an enzyme that plays a critical role in bacterial protein synthesis. To investigate how the phytocompounds interact with the enzyme's active sites, we employed a molecular docking study using Autodock Software Tools 1.5.7. Our findings revealed that all 28 phytocompounds bound to the enzyme's active sites with binding energies ranging from -6.96 to -4.03 kcal/mol. These results suggest that terpene-rich essential oils could be a potential source of novel antimicrobial agents.Communicated by Ramaswamy H. Sarma. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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