Control of working memory maintenance by theta-gamma phase amplitude coupling of human hippocampal neurons.

Autor:	Daume J; Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Center for Neural Science and Medicine, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Kaminski J; Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Nencki Institute of Experimental Biology, Warsaw, Poland., Schjetnan AGP; Krembil Research Institute and Division of Neurosurgery, University Health Network (UHN), University of Toronto, Toronto, ON, Canada., Salimpour Y; Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD, USA., Khan U; Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Reed C; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Anderson W; Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD, USA., Valiante TA; Krembil Research Institute and Division of Neurosurgery, University Health Network (UHN), University of Toronto, Toronto, ON, Canada., Mamelak AN; Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Rutishauser U; Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Center for Neural Science and Medicine, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2023 Apr 07. Date of Electronic Publication: 2023 Apr 07.
DOI:	10.1101/2023.04.05.535772
Abstrakt:	Retaining information in working memory (WM) is a demanding process that relies on cognitive control to protect memoranda-specific persistent activity from interference. How cognitive control regulates WM storage, however, remains unknown. We hypothesized that interactions of frontal control and hippocampal persistent activity are coordinated by theta-gamma phase amplitude coupling (TG-PAC). We recorded single neurons in the human medial temporal and frontal lobe while patients maintained multiple items in WM. In the hippocampus, TG-PAC was indicative of WM load and quality. We identified cells that selectively spiked during nonlinear interactions of theta phase and gamma amplitude. These PAC neurons were more strongly coordinated with frontal theta activity when cognitive control demand was high, and they introduced information-enhancing and behaviorally relevant noise correlations with persistently active neurons in the hippocampus. We show that TG-PAC integrates cognitive control and WM storage to improve the fidelity of WM representations and facilitate behavior. Competing Interests: Competing Interests Statement Authors declare no competing interests.
Databáze:	MEDLINE
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