The Potential Role of Etanercept in the Management of Post-stroke Pain: A Literature Review.

Autor:	Joseph AM; Osteopathic Medicine, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Davie, USA., Karas M; Osteopathic Medicine, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Davie, USA., Jara Silva CE; Osteopathic Medicine, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, USA., Leyva M; Osteopathic Medicine, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, USA., Salam A; General Surgery, Khyber Medical College, Peshawar, PAK., Sinha M; Research, International Society for Chronic Illnesses, Vadodara, IND.; Surgery, Kasturba Medical College, Mangalore, IND., Asfaw YA; Internal Medicine, University of Gondar, Gondar, ETH., Fonseca A; College of Medicine, American University of Integrative Sciences, Bridgetown, BRB., Cordova S; Neurology, St. Matthew's University School of Medicine, Miami, USA., Reyes M; Allopathic Medicine, American University of Antigua, Osbourn, ATG., Quinonez J; Neurology/Osteopathic Neuromuscular Medicine, Larkin Community Hospital, Miami, USA., Ruxmohan S; Neurocritical Care, University of Texas Southwestern Medical Center, Dallas, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2023 Mar 15; Vol. 15 (3), pp. e36185. Date of Electronic Publication: 2023 Mar 15 (Print Publication: 2023).
DOI:	10.7759/cureus.36185
Abstrakt:	Strokes are the second leading cause of death and disability worldwide. The brain injury resulting from stroke produces a persistent neuroinflammatory response in the brain, resulting in a spectrum of neurologic dysfunction affecting stroke survivors chronically, also known as post-stroke pain. Excess production of tumor necrosis factor alpha (TNF alpha) in the cerebrospinal fluid (CSF) of stroke survivors has been implicated in post-stroke pain. Therefore, this literature review aims to assess and review the role of perispinal etanercept in the management of post-stroke pain. Several studies have shown statistically significant evidence that etanercept, a TNF alpha inhibitor, can reduce symptoms present in post-stroke syndrome by targeting the excess TNF alpha produced in the CSF. Studies have also shown improvements in not only post-stroke pain but also in traumatic brain injury and dementia. Further research is needed to explore the effects of TNF alpha on stroke prognosis and determine the optimal frequency and duration of etanercept treatment for post-stroke pain. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Joseph et al.)
Databáze:	MEDLINE
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