Investigating the Role of Oxidative Stress in Benign Paroxysmal Positional Vertigo with Spot Urine.

Autor:	Ozdemir O; Department of Otorhinolaryngology/Head and Neck Surgery, University of Health Sciences Türkiye, Istanbul Training and Research Hospital, Istanbul, Türkiye., Aral H; Department of Medical Biochemistry, University of Health Sciences Türkiye, Istanbul Training and Research Hospital, Istanbul, Türkiye., Ruzgar H; Department of Otorhinolaryngology/Head and Neck Surgery, University of Health Sciences Türkiye, Istanbul Training and Research Hospital, Istanbul, Türkiye., Arslan HF; Department of Medical Biochemistry, Giresun University, Maternity and Children Training and Research Hospital, Giresun, Türkiye., Yigit O; Department of Otorhinolaryngology/Head and Neck Surgery, University of Health Sciences Türkiye, Istanbul Training and Research Hospital, Istanbul, Türkiye.
Jazyk:	angličtina
Zdroj:	Sisli Etfal Hastanesi tip bulteni [Sisli Etfal Hastan Tip Bul] 2023 Mar 21; Vol. 57 (1), pp. 54-60. Date of Electronic Publication: 2023 Mar 21 (Print Publication: 2023).
DOI:	10.14744/SEMB.2023.38243
Abstrakt:	Objectives: The objectives of this study were to evaluate the role of oxidative stress in benign paroxysmal positional vertigo (BPPV) by measuring urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG), 8-hydroxy-guanosine (8-OHG), and 8-hydroxy-guanine levels. Methods: Thirty-one adult female patients diagnosed with BPPV were included in this study. Patients with central pathologies and other peripheral causes of vertigo were excluded from the study. The patients were evaluated for oxidative stress during and after the BPPV attack with blood samples and spot urine tests. Depression, anxiety, and stress scale (DASS) questionnaire was used to evaluate emotional stress. A control group consisting of 30 age-matched healthy women was formed. Results: Urinary oxidative stress values during the attack were significantly higher than the post-treatment group and the healthy control group (p<0.05). There was no significant difference between the urinary oxidative stress values of the BPPV group after treatment and the healthy control group (p>0.05). DASS scores were significantly higher during the attack and after the treatment compared to the healthy control group (p<0.05). Conclusion: The increase in spot urinary 8-OHdG, 8-OHG, and 8-hydroxy-guanine levels can be used as a biomarker for oxidative stress in patients with BPPV. Furthermore, emotional stress can also trigger BPPV attacks by increasing oxidative stress. Competing Interests: None declared. (©Copyright 2023 by The Medical Bulletin of Sisli Etfal Hospital.)
Databáze:	MEDLINE
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