Diabetogenic viruses: linking viruses to diabetes mellitus.

Autor:	Rajsfus BF; Instituto de Biofísica Carlos Chagas Filho, Laboratório de Biotecnologia e Bioengenharia Estrutural, Universidade Federal do Rio de Janeiro, RJ, 21941-902, Brazil., Mohana-Borges R; Instituto de Biofísica Carlos Chagas Filho, Laboratório de Biotecnologia e Bioengenharia Estrutural, Universidade Federal do Rio de Janeiro, RJ, 21941-902, Brazil., Allonso D; Departamento de Biotecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, RJ, 21941-902, Brazil.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2023 Mar 30; Vol. 9 (4), pp. e15021. Date of Electronic Publication: 2023 Mar 30 (Print Publication: 2023).
DOI:	10.1016/j.heliyon.2023.e15021
Abstrakt:	Diabetes Mellitus (DM) is a group of chronic metabolic diseases distinguished by elevated glycemia due to the alterations in insulin metabolism. DM is one of the most relevant diseases of the modern world, with high incidence and prevalence worldwide, associated with severe systemic complications and increased morbidity and mortality rates. Although genetic factors and lifestyle habits are two of the main factors involved in DM onset, viral infections, such as enteroviruses, cytomegalovirus, hepatitis C virus, human immunodeficiency virus, severe acute respiratory syndrome coronavirus 2, among others, have been linked as triggers of type 1 (T1DM) and type 2 (T2DM) diabetes. Over the years, various groups identified different mechanisms as to how viruses can promote these metabolic syndromes. However, this field is still poorly explored and needs further research, as millions of people live with these pathologies. Thus, this review aims to ex-plore the different processes of how viruses can induce DM and their contribution to the prevalence and incidence of DM worldwide. (©2023PublishedbyElsevierLtd.)
Databáze:	MEDLINE
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