Chemistry, Biosynthesis and Pharmacology of Streptonigrin: An Old Molecule with Future Prospects for New Drug Design, Development and Therapy.

Autor:	Nabihah Nasir N; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Health Sciences, Royal College of Medicine Perak, Universiti Kuala Lumpur, Ipoh, Perak, 30450, Malaysia., Sekar M; School of Pharmacy, Monash University Malaysia, Bandar Sunway, Selangor, 47500, Malaysia.; Center for Transdisciplinary Research, Department of Pharmacology, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College and Hospital, Saveetha University, Chennai, Tamil Nadu, 600077, India., Ravi S; Department of Chemistry, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu, 641021, India., Wong LS; Faculty of Health and Life Sciences, INTI International University, Nilai, 71800, Malaysia., Sisinthy SP; Faculty of Pharmacy and Health Sciences, Royal College of Medicine Perak, Universiti Kuala Lumpur, Ipoh, Perak, 30450, Malaysia., Gan SH; School of Pharmacy, Monash University Malaysia, Bandar Sunway, Selangor, 47500, Malaysia., Subramaniyan V; Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Subang Jaya, Selangor, Malaysia., Chidambaram K; Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, 62529, Saudi Arabia., Mat Rani NNI; Faculty of Pharmacy and Health Sciences, Royal College of Medicine Perak, Universiti Kuala Lumpur, Ipoh, Perak, 30450, Malaysia., Begum MY; Department of Pharmaceutics, College of Pharmacy, King Khalid University, Abha, 61421, Saudi Arabia., Ramar M; Department of Surgical Research, Rhode Island Hospital, Alpert Medical School, Brown University, Providence, RI, 02903, USA., Safi SZ; Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jenjarom, Selangor, 42610, Malaysia., Selvaraj S; Faculty of Dentistry, AIMST University, Bedong, Kedah, 08100, Malaysia., Chinna Maruthu SK; Department of Pharmacology, Karpagam College of Pharmacy, Coimbatore, Tamilnadu, 641032, India., Fuloria S; Faculty of Pharmacy, AIMST University, Bedong, Kedah, 08100, Malaysia., Fuloria NK; Faculty of Pharmacy, AIMST University, Bedong, Kedah, 08100, Malaysia., Lum PT; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Health Sciences, Royal College of Medicine Perak, Universiti Kuala Lumpur, Ipoh, Perak, 30450, Malaysia., Djearamane S; Department of Biomedical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Kampar, Perak, 31900, Malaysia.
Jazyk:	angličtina
Zdroj:	Drug design, development and therapy [Drug Des Devel Ther] 2023 Apr 08; Vol. 17, pp. 1065-1078. Date of Electronic Publication: 2023 Apr 08 (Print Publication: 2023).
DOI:	10.2147/DDDT.S388490
Abstrakt:	Streptonigrin is an aminoquinone alkaloid isolated from Streptomyces flocculus and is gaining attention as a drug molecule owing to its potential antitumor and antibiotic effects. It was previously used as an anticancer drug but has been discontinued because of its toxic effects. However, according to the most recent studies, the toxicity of streptonigrin and its structurally modified derivatives has been reduced while maintaining their potential pharmacological action at lower concentrations. To date, many investigations have been conducted on this molecule and its derivatives to determine the most effective molecule with low toxicity to enable new drug discovery. Therefore, the main objective of this study is to provide a comprehensive review and to discuss the prospects for streptonigrin and its derived compounds, which may boost the molecule as a highly interesting target molecule for new drug design, development and therapy. To complete this review, relevant literature was collected from several scientific databases, including Google Scholar, PubMed, Scopus and ScienceDirect. Following a complete screening, the obtained information is summarized in the present review to provide a good reference and accelerate the development and utilization of streptonigrin and its derivatives as pharmaceuticals. Competing Interests: The authors declare that they have no conflicts of interest. (© 2023 Nabihah Nasir et al.)
Databáze:	MEDLINE
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