The assessment of executive functions to test the integrity of the nigrostriatal network: A pilot study.

Autor:	Ilardi CR; IRCCS Synlab SDN, Naples, Italy., di Maio G; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy., Villano I; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy., Messina G; Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy., Monda V; Department of Movement Sciences and Wellbeing, University of Naples 'Parthenope', Naples, Italy., Messina A; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy., Porro C; Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy., Panaro MA; Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy., Gamboz N; Laboratory of Experimental Psychology, Suor Orsola Benincasa University, Naples, Italy., Iavarone A; Neurological Unit, CTO Hospital, AORN 'Ospedali dei Colli', Naples, Italy., La Marra M; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.
Jazyk:	angličtina
Zdroj:	Frontiers in psychology [Front Psychol] 2023 Mar 29; Vol. 14, pp. 1121251. Date of Electronic Publication: 2023 Mar 29 (Print Publication: 2023).
DOI:	10.3389/fpsyg.2023.1121251
Abstrakt:	Background: Parkinson's disease (PD) is a chronic neurodegenerative disorder characterized by motor and non-motor symptoms. The latter mainly include affective, sleep, and cognitive deficits. Non-demented PD patients often demonstrate impairments in several executive domains following neuropsychological evaluation. The current pilot study aims at assessing the discriminatory power of the Frontal Assessment Battery-15 (FAB15) in differentiating (i) non-demented PD patients and healthy controls and (ii) PD patients with more and less pronounced motor symptoms. Methods: Thirty-nine non-demented early-stage PD patients in the "on" dopamine state (26 females, mean age = 64.51 years, SD = 6.47, mean disease duration = 5.49 years, SD = 2.28) and 39 healthy participants (24 females, mean age = 62.60 years, SD = 5.51) were included in the study. All participants completed the FAB15. Motor symptoms of PD patients were quantified via the Unified Parkinson's Disease Rating Scale-Part III (UPDRS-Part III) and Hoehn and Yahr staging scale (H&Y). Results: The FAB15 score, adjusted according to normative data for sex, age, and education, proved to be sufficiently able to discriminate PD patients from healthy controls (AUC = 0.69 [95% CI 0.60-0.75], SE = 0.06, p = 0.04, optimal cutoff = 11.29). Conversely, the battery lacked sufficient discriminative capability to differentiate PD patients based on the severity of motor symptoms. Conclusion: The FAB15 may be a valid tool for distinguishing PD patients from healthy controls. However, it might be less sensitive in identifying clinical phenotypes characterized by visuospatial impairments resulting from posteroparietal and/or temporal dysfunctions. In line with previous evidence, the battery demonstrated to be not expendable in the clinical practice for monitoring the severity of PD-related motor symptoms. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Ilardi, di Maio, Villano, Messina, Monda, Messina, Porro, Panaro, Gamboz, Iavarone and La Marra.)
Databáze:	MEDLINE
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