Memory B cells and serum immunoglobulins are associated with disease severity and mortality in patients with COVID-19.

Autor:	Çölkesen F; Division of Clinical Immunology and Allergy, Department of Internal Medicine, Necmettin Erbakan University Meram Faculty of Medicine, Konya, Turkey., Kurt EK; Department of Infectious Diseases and Clinical Microbiology, Necmettin Erbakan University Meram Faculty of Medicine, Konya, Turkey., Vatansev H; Department of Chest Diseases, Necmettin Erbakan University Meram Faculty of Medicine, Konya, Turkey., Korkmaz C; Department of Chest Diseases, Necmettin Erbakan University Meram Faculty of Medicine, Konya, Turkey., Çölkesen F; Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey., Yücel F; Department of General Intensive Care Unit, Konya Training and Research Hospital, Konya, Turkey., Yıldız E; Division of Clinical Immunology and Allergy, Department of Internal Medicine, Necmettin Erbakan University Meram Faculty of Medicine, Konya, Turkey., Evcen R; Division of Clinical Immunology and Allergy, Department of Internal Medicine, Necmettin Erbakan University Meram Faculty of Medicine, Konya, Turkey., Aykan FS; Division of Clinical Immunology and Allergy, Department of Internal Medicine, Necmettin Erbakan University Meram Faculty of Medicine, Konya, Turkey., Kılınç M; Division of Clinical Immunology and Allergy, Department of Internal Medicine, Necmettin Erbakan University Meram Faculty of Medicine, Konya, Turkey., Aytekin G; Division of Clinical Immunology and Allergy, Department of Internal Medicine, Konya Training and Research Hospital, Konya, Turkey., Feyzioğlu B; Division of Medical Virology, Department of Medical Microbiology, Necmettin Erbakan University Meram Faculty of Medicine, Konya, Turkey., Doğan M; Department of Medical Microbiology, Necmettin Erbakan University Meram Faculty of Medicine, Konya, Turkey., Arslan Ş; Division of Clinical Immunology and Allergy, Department of Internal Medicine, Necmettin Erbakan University Meram Faculty of Medicine, Konya, Turkey., Teke T; Department of Chest Diseases, Necmettin Erbakan University Meram Faculty of Medicine, Konya, Turkey., Keleş S; Division of Pediatric Allergy and Immunology, Necmettin Erbakan University Meram Faculty of Medicine, Konya, Turkey., Reisli İ; Division of Pediatric Allergy and Immunology, Necmettin Erbakan University Meram Faculty of Medicine, Konya, Turkey.
Jazyk:	angličtina
Zdroj:	Postgraduate medical journal [Postgrad Med J] 2022 Oct 01; Vol. 98 (1164), pp. 765-771.
DOI:	10.1136/postgradmedj-2021-140540
Abstrakt:	Purpose of the Study: The aim of this study was to investigate the relationship of B cell-mediated immunity with disease severity and mortality in patients with COVID-19. Study Design: In this retrospective cohort and single-centre study, 208 patients with laboratory-confirmed COVID-19 were recruited. A COVID-19 severity score, ranging from 0 to 10, was used to evaluate associations between various factors. Serum immunoglobulin levels and the number of cells in B lymphocyte subsets were measured and their association with disease severity and mortality in patients with COVID-19 examined. Results: The median age of the patients was 50 (35-63) years and 88 (42%) were female. The number of deceased patients was 17. The median COVID-19 severity score was 8 (6-8) in deceased patients and 1 (0-2) in survivors. Deceased patients had significantly lower levels of total B lymphocytes, naive B cells, switched memory B cells, and serum IgA, IgG, IgG1 and IgG2 than recovered patients (all p<0.05). In addition, a significant negative correlation was found between the number of these parameters and COVID-19 severity scores. Decrease in the number of total B cells and switched memory B cells as well as lower serum IgA, IgG and IgG1 levels were independent risk factors for mortality in patients with COVID-19. Conclusion: In the present study, the prognosis of patients with COVID-19 was shown to be associated with the B cell subset and serum immunoglobulin levels. (© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu