α-D-Glucose as a non-radioactive MRS tracer for metabolic studies of the brain.

Autor: Weng G; Institute for Diagnostic and Interventional Neuroradiology, Support Center for Advanced Neuroimaging (SCAN), Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland.; Translational Imaging Center, Sitem-Insel, Bern, Switzerland., Radojewski P; Institute for Diagnostic and Interventional Neuroradiology, Support Center for Advanced Neuroimaging (SCAN), Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland.; Translational Imaging Center, Sitem-Insel, Bern, Switzerland., Slotboom J; Institute for Diagnostic and Interventional Neuroradiology, Support Center for Advanced Neuroimaging (SCAN), Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland. Johannes.Slotboom@insel.ch.; Translational Imaging Center, Sitem-Insel, Bern, Switzerland. Johannes.Slotboom@insel.ch.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Apr 15; Vol. 13 (1), pp. 6159. Date of Electronic Publication: 2023 Apr 15.
DOI: 10.1038/s41598-023-33161-8
Abstrakt: Changes in brain glucose metabolism occur in many neurological disorders as well as during aging. Most studies on the uptake of glucose in the brain use positron emission tomography, which requires injection of a radioactive tracer. Our study shows that ultra-high-field 1 H-MRS can be used to measure α-D-glucose at 5.22 ppm in vivo, and the α-D-glucose can be used as a radiation-free tracer in the human brain.
(© 2023. The Author(s).)
Databáze: MEDLINE
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