Forensic application of aquaporins.

Autor: Ishida Y; Department of Forensic Medicine, Wakayama Medical University, Wakayama, Japan. Electronic address: iyuko@wakayama-med.ac.jp., Nosaka M; Department of Forensic Medicine, Wakayama Medical University, Wakayama, Japan., Ishigami A; Department of Forensic Medicine, Wakayama Medical University, Wakayama, Japan., Kondo T; Department of Forensic Medicine, Wakayama Medical University, Wakayama, Japan. Electronic address: kondot@wakayama-med.ac.jp.
Jazyk: angličtina
Zdroj: Legal medicine (Tokyo, Japan) [Leg Med (Tokyo)] 2023 Jul; Vol. 63, pp. 102249. Date of Electronic Publication: 2023 Mar 31.
DOI: 10.1016/j.legalmed.2023.102249
Abstrakt: Aquaporins (AQPs) are a family of water channel proteins that primarily elicit the basic functions of water transport and osmotic homeostasis. To date, at least 17 mammalian AQPs have been identified, AQP-0 to -12 have been found in higher orders including human, and AQP-13 to -16 have been described in older lineages. Moreover, these proteins have recently been shown to regulate many biological processes through unique activities, such as cell proliferation, migration, apoptosis, and mitochondrial metabolism. Several studies have focused on the involvement of AQPs in cell biology aspect, showing that they are involved in a variety of physiological processes and pathophysiological conditions. Furthermore, in the field of forensic medicine, studies on whether AQPs can be a useful marker for diagnosing various causes of death have been conducted using autopsy samples and animal experiments, which have produced interesting results. Herein, we review certain observations regarding AQPs and discuss their potential to contribute to the future practice of forensic research.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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