Factors affecting urinary organophosphate pesticide metabolite levels among Californian agricultural community members.

Autor: Kuiper G; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA., Young BN; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA., WeMott S; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA., Erlandson G; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA., Martinez N; Central California Environmental Justice Network, Fresno, CA, USA., Mendoza J; Central California Environmental Justice Network, Fresno, CA, USA., Dooley G; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA., Quinn C; Department of Mechanical Engineering, Colorado State University, Fort Collins, CO, USA., Benka-Coker W; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA; Department of Environmental Studies, Dickinson College, Carlisle, PA, USA., Magzamen S; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA. Electronic address: sheryl.magzamen@colostate.edu.
Jazyk: angličtina
Zdroj: The Science of the total environment [Sci Total Environ] 2023 Jul 10; Vol. 881, pp. 163362. Date of Electronic Publication: 2023 Apr 12.
DOI: 10.1016/j.scitotenv.2023.163362
Abstrakt: Organophosphate (OP) pesticides are widely used in California for agricultural pest and weed control despite their well-documented adverse health effects among infants, children, and adults. We sought to identify factors affecting urinary OP metabolites among families living in high-exposure communities. Our study included 80 children and adults who lived within 61 m (200 ft) of agricultural fields in the Central Valley of California in January and June 2019, which are pesticide non-spraying and spraying seasons, respectively. We collected one urine sample per participant during each visit to measure dialkyl phosphate (DAP) metabolites; these were coupled with in-person surveys to identify health, household, sociodemographic, pesticide exposure, and occupational risk factors. We used a data-driven, best subsets regression approach to identify key factors that influenced urinary DAPs. Participants were mostly Hispanic/Latino(a) (97.5 %), over half were female (57.5 %), and most households reported having a member who worked in agriculture (70.6 %). Among the 149 urine samples suitable for analysis, DAP metabolites were detected in 48.0 % and 40.5 % of samples during January and June, respectively. Total diethyl alkylphosphates (EDE) were only detected in 4.7 % (n = 7) of samples, but total dimethyl alkylphosphates (EDM) were detected in 41.6 % (n = 62) of samples. No differences were observed in urinary DAP levels by visit month or by occupational exposure to pesticides. Best subsets regression identified several individual- and household-level variables that influenced both urinary EDM and total DAPs: the number of years spent living at the current address, household use of chemical products to control mice/rodents, and seasonal employment status. Among adults only, we identified educational attainment (for total DAPs) and age category (for EDM) as significant factors. Our study found consistent urinary DAP metabolites among participants, regardless of spraying season, and identified potential mitigating factors that members of vulnerable populations can implement to protect their health against OP exposure.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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