Reduced peripheral and respiratory muscle strength in pediatric patients after kidney transplantation.

Autor:	Frantzeski MH; Universidade Federal de Ciências da Saúde de Porto Alegre, Programa de Pós-Graduação em Ciências da Reabilitação, Porto Alegre, RS, Brazil., Thomazi CPF; Centro Universitário Cenecista de Osório, Osório, RS, Brazil., Pinho ASD; Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil., Garcia CD; Complexo Hospitalar Santa Casa de Porto Alegre-Hospital da Criança Santo Antônio, Departamento de Nefrologia Pediátrica, Porto Alegre, RS, Brazil., Lukrafka JL; Universidade Federal de Ciências da Saúde de Porto Alegre, Departamento de Fisioterapia, Porto Alegre, RS, Brazil.
Jazyk:	English; Portuguese
Zdroj:	Jornal brasileiro de nefrologia [J Bras Nefrol] 2023 Jul-Sep; Vol. 45 (3), pp. 318-325.
DOI:	10.1590/2175-8239-JBN-2022-0096en
Abstrakt:	Introduction: Reduced muscle strength and low-exercise capacity are well documented in adults, but there are few studies examining those impairments in children and adolescents after kidney transplantation. The objective of this study was to evaluate peripheral and respiratory muscle strength and the association with submaximal exercise capacity in children and adolescents after kidney transplant. Methods: Forty-seven patients between six and 18 years of age clinically stable after transplantation were included. Peripheral muscle strength (isokinetic and hand-grip dynamometry), respiratory muscle strength (maximal inspiratory and expiratory pressure), and submaximal exercise capacity (six-minute walk test - 6MWT) were assessed. Results: Patients had a mean age of 13.1 ± 2.7 years and an average of 34 months had elapsed since the transplantation. Flexors of the knee showed a significant reduction in muscle strength (77.3% of predicted) and knee extensors had normal values (105.4% of predicted). Hand-grip strength and maximal respiratory pressures (inspiratory and expiratory) also were significantly lower than expected (p < 0.001). Although distance walked in the 6MWT was significantly lower than predicted (p < 0.001), no significant correlation was found with peripheral and respiratory muscle strength. Conclusion: Children and adolescents after kidney transplantation have reduced peripheral muscle strength of knee flexors, hand-grip, and maximal respiratory pressures. No associations were found between peripheral and respiratory muscle strength and submaximal exercise capacity.
Databáze:	MEDLINE
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