Interhemispheric transfer time and concussion in adolescents: A longitudinal study using response time and event-related potential measures.

Autor:	Christensen BA; Neuroscience Center, Brigham Young University, Provo, UT, United States.; Department of Psychology, Brigham Young University, Provo, UT, United States., Clark B; Neuroscience Center, Brigham Young University, Provo, UT, United States., Muir AM; Department of Psychology, Brigham Young University, Provo, UT, United States., Allen WD; Department of Psychology, Brigham Young University, Provo, UT, United States., Corbin EM; Neuroscience Center, Brigham Young University, Provo, UT, United States., Jaggi T; Pacific Northwest University of Health Sciences, Yakima, WA, United States., Alder N; University of Utah School of Medicine, Salt Lake City, UT, United States., Clawson A; Children's National Hospital, Washington, DC, United States., Farrer TJ; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United States., Bigler ED; Neuroscience Center, Brigham Young University, Provo, UT, United States.; Department of Psychology, Brigham Young University, Provo, UT, United States.; Departments of Psychiatry and Neurology, University of Utah, Salt Lake City, UT, United States., Larson MJ; Neuroscience Center, Brigham Young University, Provo, UT, United States.; Department of Psychology, Brigham Young University, Provo, UT, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in human neuroscience [Front Hum Neurosci] 2023 Mar 28; Vol. 17, pp. 1161156. Date of Electronic Publication: 2023 Mar 28 (Print Publication: 2023).
DOI:	10.3389/fnhum.2023.1161156
Abstrakt:	Introduction: Concussion in children and adolescents is a public health concern with higher concussion incidence than adults and increased susceptibility to axonal injury. The corpus callosum is a vulnerable location of concussion-related white matter damage that can be associated with short- and long-term effects of concussion. Interhemispheric transfer time (IHTT) of visual information across the corpus callosum can be used as a direct measure of corpus callosum functioning that may be impacted by adolescent concussion with slower IHTT relative to matched controls. Longitudinal studies and studies testing physiological measures of IHTT following concussion in adolescents are lacking. Methods: We used the N1 and P1 components of the scalp-recorded brain event-related potential (ERP) to measure IHTT in 20 adolescents (ages 12-19 years old) with confirmed concussion and 16 neurologically-healthy control participants within 3 weeks of concussion (subacute stage) and approximately 10 months after injury (longitudinal). Results: Separate two-group (concussion, control) by two-time (3 weeks, 10 months) repeated measures ANOVAs on difference response times and IHTT latencies of the P1 and N1 components showed no significant differences by group ( p s ≥ 0.25) nor by time ( p s ≥ 0.64), with no significant interactions ( p s ≥ 0.15). Discussion: Results from the current sample suggest that measures of IHTT may not be strongly influenced at 3 weeks or longitudinally following adolescent concussion using the current IHTT paradigm. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Christensen, Clark, Muir, Allen, Corbin, Jaggi, Alder, Clawson, Farrer, Bigler and Larson.)
Databáze:	MEDLINE
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