Pediatric diffuse hemispheric glioma H3 G34-mutant with gains of the BRAF locus: An illustrative case.

Autor: Marlow C; Virginia Tech Carilion School of Medicine, Roanoke, VA, USA., Cuoco JA; Virginia Tech Carilion School of Medicine, Roanoke, VA, USA.; Section of Neurosurgery, Carilion Clinic, Roanoke, VA, USA.; School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA., Hoggarth AR; Virginia Tech Carilion School of Medicine, Roanoke, VA, USA.; Section of Neurosurgery, Carilion Clinic, Roanoke, VA, USA.; School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA., Stump MS; Virginia Tech Carilion School of Medicine, Roanoke, VA, USA.; Department of Pathology, Carilion Clinic, Roanoke, VA, USA., Apfel LS; Virginia Tech Carilion School of Medicine, Roanoke, VA, USA.; Section of Neurosurgery, Carilion Clinic, Roanoke, VA, USA.; School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA., Rogers CM; Virginia Tech Carilion School of Medicine, Roanoke, VA, USA.; Section of Neurosurgery, Carilion Clinic, Roanoke, VA, USA.; School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
Jazyk: angličtina
Zdroj: Rare tumors [Rare Tumors] 2023 Apr 07; Vol. 15, pp. 20363613231168704. Date of Electronic Publication: 2023 Apr 07 (Print Publication: 2023).
DOI: 10.1177/20363613231168704
Abstrakt: Diffuse hemispheric glioma, H3 G34-mutant, is a recently recognized distinct high-grade glioma with a dismal prognosis. In addition to the H3 G34 missense mutation, numerous genetic events have been identified in these malignant tumors, including ATRX , TP53 , and, rarely, BRAF genes. There are only a few reports to date that have identified BRAF mutations in diffuse hemispheric glioma, H3 G34-mutant. Moreover, to our knowledge, gains of the BRAF locus have yet to be described. Here, we present a case of an 11-year-old male with a diffuse hemispheric glioma, H3 G34-mutant, found to have novel gains of the BRAF locus. Furthermore, we emphasize the current genetic landscape of diffuse hemispheric glioma, H3 G34-mutant, and implications of an aberrant BRAF signaling pathway.
Competing Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
(© The Author(s) 2023.)
Databáze: MEDLINE
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