Pericapsular nerve group (PENG) block for early pain management of elderly patients with hip fracture: a single-center double-blind randomized controlled trial.

Autor:	Lin X; Division of Anaesthesiology and Perioperative Medicine, Singapore General Hospital, Singapore., Liu CW; Pain Medicine, Singapore General Hospital, Singapore., Goh QY; Division of Anaesthesiology and Perioperative Medicine, Singapore General Hospital, Singapore., Sim EY; The Anaesthetic Clinic @ Alvernia, Mount Alvernia Hospital, Singapore., Chan SKT; Division of Anaesthesiology and Perioperative Medicine, Singapore General Hospital, Singapore., Lim ZW; Division of Anaesthesiology and Perioperative Medicine, Singapore General Hospital, Singapore., Chan DXH; Division of Anaesthesiology and Perioperative Medicine, Singapore General Hospital, Singapore diana.chan.x.h@singhealth.com.sg.; Pain Medicine, Singapore General Hospital, Singapore.
Jazyk:	angličtina
Zdroj:	Regional anesthesia and pain medicine [Reg Anesth Pain Med] 2023 Nov; Vol. 48 (11), pp. 535-539. Date of Electronic Publication: 2023 Apr 13.
DOI:	10.1136/rapm-2022-104117
Abstrakt:	Background: The pericapsular nerve group block (PENG) is a novel technique that blocks the articular branches of the hip joint. This study aimed to compare its effectiveness to a sham block in elderly patients with hip fractures. Method: A randomized double-blind controlled trial was conducted in elderly patients with intertrochanteric and neck of femur fractures. Patients were randomized to receive either PENG block or a sham block. Postblock, systemic analgesia was titrated using a standardized protocol of acetaminophen, oral morphine or patient-controlled analgesia. The primary outcome was the dynamic pain score (Numerical Rating Scale 0-10) at 30 min postblock. Secondary outcomes included pain scores at multiple other time points and 24-hour opioid consumption. Results: 60 patients were randomized and 57 completed the trial (PENG n=28, control n=29). Patients in PENG group had significantly lower dynamic pain scores at 30 min compared with control group (median (IQR) 3 (0.5-5) vs 5 (3-10), p<0.01). For the secondary outcomes, dynamic pain scores were lower in PENG group at 1 hour (median (IQR) 2 (1-3.25) vs 5 (3-8), p<0.01) and 3 hours postblock (median (IQR) 2 (0-5) vs 5 (2-8), p<0.05). Patients in PENG group had lower 24-hour opioid consumption (median (IQR) oral morphine equivalent dose 10 (0-15) vs 15 (10-30) mg, p<0.05). Conclusion: PENG block provided effective analgesia for acute traumatic pain following hip fracture. Further studies are required to validate the superiority of PENG blocks over other regional techniques. Trial Registration Number: NCT04996979. Competing Interests: Competing interests: None declared. (© American Society of Regional Anesthesia & Pain Medicine 2023. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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