Interaction of nicotine and social reward in group-reared male adolescent rats.

Autor: Cortés-Patiño DM; Universidad Nacional de Colombia, Colombia., Neira VM; Universidad Nacional de Colombia, Colombia., Ballesteros-Acosta H; Universidad Nacional de Colombia, Colombia., Bustos-Rangel A; Universidad Nacional de Colombia, Colombia., Lamprea MR; Universidad Nacional de Colombia, Colombia. Electronic address: mlamprear@unal.edu.co.
Jazyk: angličtina
Zdroj: Behavioural brain research [Behav Brain Res] 2023 Jun 05; Vol. 447, pp. 114432. Date of Electronic Publication: 2023 Apr 11.
DOI: 10.1016/j.bbr.2023.114432
Abstrakt: Adolescents exhibit great sensitivity to nicotine and social interaction; accordingly, when both stimuli are presented together, they interact to enhance the incentive value of the context in which they occur. Noteworthy, most studies assessing the interaction between nicotine and social reward have used isolated-reared rats. Adolescent isolation is an adverse condition that impacts brain development and behavior, so it is not known if the interaction also occurs in rats without social deprivation. The present study used a conditioned place preference model (CPP) to examine the interaction between nicotine and social reward in group-reared male adolescent rats. At weaning, Wistar rats were randomly assigned to four groups: vehicle, vehicle and a social partner, nicotine (0.1 mg/Kg s.c.), and nicotine and a social partner. Conditioning trials occurred on eight consecutive days followed by a test session in which the preference change was assessed. Besides the establishment of CPP, we examined the effects of nicotine on (1) social behaviors during CPP trials and (2) tyrosine hydroxylase (TH) and oxytocin (OT) as markers of changes in the neuronal mechanisms for reward and social affiliation. Similar to previous results, the joint presentation of nicotine and social reward induced CPP, whereas either nicotine or social interaction presented alone did not. This finding coincided with an increase in TH levels observed after nicotine administration only in socially conditioned rats. The interaction between nicotine and social reward is not related to the effects of nicotine on social investigation or social play.
Competing Interests: Conflict of interest The authors do not have any conflicts of interest to report in connection with this manuscript.
(Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: