Guanidinoacetic acid in human nutrition: Beyond creatine synthesis.

Autor: Ostojic SM; Applied Bioenergetics Lab, Faculty of Sport and Physical Education University of Novi Sad Novi Sad Serbia.; Department of Nutrition and Public Health University of Agder Kristiansand Norway.; Faculty of Health Sciences University of Pécs Pécs Hungary., Jorga J; Department of Hygiene and Medical Ecology, School of Medicine University of Belgrade Beograd Serbia.
Jazyk: angličtina
Zdroj: Food science & nutrition [Food Sci Nutr] 2023 Jan 11; Vol. 11 (4), pp. 1606-1611. Date of Electronic Publication: 2023 Jan 11 (Print Publication: 2023).
DOI: 10.1002/fsn3.3201
Abstrakt: Guanidinoacetic acid (GAA) is a nutrient that has been used in human nutrition since the early 1950s. Recommended for its role in creatine biosynthesis, GAA demonstrated beneficial energy-boosting effects in various clinical conditions. Dietary GAA has also been suggested to trigger several creatine-independent mechanisms. Besides acting as a direct precursor of high-energy phosphagen creatine, dietary GAA is suggested to reduce blood glucose concentration by acting as an insulinotropic food compound, spare amino acid arginine for other metabolic purposes (including protein synthesis), modulate taste, and perhaps alter methylation and fat deposition in various organs including the liver. GAA as a food component can have several important metabolic roles beyond creatine biosynthesis; future studies are highly warranted to address GAA overall role in human nutrition.
Competing Interests: SMO serves as a member of the Scientific Advisory Board on creatine in health and medicine (AlzChem LLC). SMO co‐owns patent “Supplements Based on Liquid Creatine” at European Patent Office (WO2019150323 A1), patent “Methods and Compositions for Improving a Response to a Metabolic Stress” at United States Patent and Trademark Office (US 2015/0150933 A1), and patent “Agent for Inhibiting Deterioration of Recognition Function Comprising Hydrogen Gas” at Japan Patent Office (ID 2016‐163,322). SMO has served as a speaker at Abbott Nutrition and has received research funding related to nutrition during the past 36 months from The World Health Organization, Serbian Ministry of Education, Science, and Technological Development, Provincial Secretariat for Higher Education and Scientific Research, Allied Beverages Adriatic, AlzChem GmbH, ThermoLife International, Hueston Hennigan LLP, HRW Natural Health Products Inc, Aktivátor Kft, and CarnoMed. SMO does not own stocks and shares in any organization. JJ declares no conflict of interest.
(© 2023 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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