Neutralization of alpha-bungarotoxin by monoclonal antibodies.

Autor: Danse JM, Toussaint JL, Kempf J
Jazyk: angličtina
Zdroj: Toxicon : official journal of the International Society on Toxinology [Toxicon] 1986; Vol. 24 (2), pp. 141-51.
DOI: 10.1016/0041-0101(86)90116-9
Abstrakt: We have produced monoclonal antibodies against alpha-bungarotoxin from Bungarus multicinctus, and controls were performed for their specificity and monoclonal character. The antibodies protected mice against the toxic effect of alpha-bungarotoxin for a few hours to six days, depending upon the chosen antibody (in comparison to a survival time of 79 min for the standard toxin dose). Antibodies can be grouped in several sets according to their duration of protection.
Databáze: MEDLINE