Different Effects of Cyclical Ketogenic vs. Nutritionally Balanced Reduction Diet on Serum Concentrations of Myokines in Healthy Young Males Undergoing Combined Resistance/Aerobic Training.

Autor:	Kysel P; Department of Sports Medicine, First Faculty of Medicine and General University Hospital, 128 08 Prague, Czech Republic., Haluzíková D; Department of Sports Medicine, First Faculty of Medicine and General University Hospital, 128 08 Prague, Czech Republic., Pleyerová I; Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic., Řezníčková K; Diabetes Centre, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic., Laňková I; Diabetes Centre, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic., Lacinová Z; Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic.; Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital, 121 11 Prague, Czech Republic., Havrlantová T; Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic., Mráz M; Diabetes Centre, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic., Kasperová BJ; Diabetes Centre, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic., Kovářová V; Diabetes Centre, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic., Thieme L; Diabetes Centre, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic., Trnovská J; Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic., Svoboda P; Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic.; Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Technicka 5, 166 28 Prague, Czech Republic., Hubáčková SŠ; Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic., Vilikus Z; Department of Sports Medicine, First Faculty of Medicine and General University Hospital, 128 08 Prague, Czech Republic., Haluzík M; Diabetes Centre, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic.; Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital, 121 11 Prague, Czech Republic.
Jazyk:	angličtina
Zdroj:	Nutrients [Nutrients] 2023 Mar 31; Vol. 15 (7). Date of Electronic Publication: 2023 Mar 31.
DOI:	10.3390/nu15071720
Abstrakt:	Myokines represent important regulators of muscle metabolism. Our study aimed to explore the effects of a cyclical ketogenic reduction diet (CKD) vs. a nutritionally balanced reduction diet (RD) combined with regular resistance/aerobic training in healthy young males on serum concentrations of myokines and their potential role in changes in physical fitness. Twenty-five subjects undergoing regular resistance/aerobic training were randomized to the CKD ( n = 13) or RD ( n = 12) groups. Anthropometric and spiroergometric parameters, muscle strength, biochemical parameters, and serum concentrations of myokines and cytokines were assessed at baseline and after 8 weeks of intervention. Both diets reduced body weight, body fat, and BMI. Muscle strength and endurance performance were improved only by RD. Increased musclin (32.9 pg/mL vs. 74.5 pg/mL, p = 0.028) and decreased osteonectin levels (562 pg/mL vs. 511 pg/mL, p = 0.023) were observed in RD but not in the CKD group. In contrast, decreased levels of FGF21 (181 pg/mL vs. 86.4 pg/mL, p = 0.003) were found in the CKD group only. Other tested myokines and cytokines were not significantly affected by the intervention. Our data suggest that changes in systemic osteonectin and musclin levels could contribute to improved muscle strength and endurance performance and partially explain the differential effects of CKD and RD on physical fitness.
Databáze:	MEDLINE
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