| Autor: |
Cazzador D; Otolaryngology Section, Department of Neuroscience DNS, University of Padova, 35100 Padova, Italy., Franz L; Otolaryngology Section, Department of Neuroscience DNS, University of Padova, 35100 Padova, Italy., Tealdo G; Otolaryngology Section, Department of Neuroscience DNS, University of Padova, 35100 Padova, Italy., Carobbio ALC; Otolaryngology Section, Department of Neuroscience DNS, University of Padova, 35100 Padova, Italy., Ferraro M; Otolaryngology Section, Department of Neuroscience DNS, University of Padova, 35100 Padova, Italy., Mazzoni A; Otolaryngology Section, Department of Neuroscience DNS, University of Padova, 35100 Padova, Italy., Marioni G; Phoniatrics and Audiology Unit, Department of Neuroscience DNS, University of Padova, 31100 Treviso, Italy., Zanoletti E; Otolaryngology Section, Department of Neuroscience DNS, University of Padova, 35100 Padova, Italy. |
| Abstrakt: |
Squamous cell carcinomas (SCC) of the external auditory canal (EAC) are rare tumors representing a surgical challenge. Current knowledge is based largely on case series; thus, the level of evidence is weak. This study sought to systematically review the available SCC of the EAC literature and to identify risk factors for overall survival (OS) and disease-specific survival (DSS). A systematic review and meta-analysis of papers searched up to December 2022 through PubMed, Scopus, Web of Science, and Cochrane Library databases was conducted. Quality assessment of the eligible studies was done according to the Newcastle-Ottawa Scale. Pooled univariate and multivariable analyses and meta-analysis using a random-effects or fixed-effects Mantel-Haenszel model were performed. Fifteen articles (282 patients) met the inclusion criteria and were included in the quantitative analysis. The pooled multivariable analysis revealed cT3 and cT4 as independent prognostic factors for OS ( p = 0.005, and p < 0.001, respectively) and DSS ( p = 0.002, and p < 0.001, respectively). Local recurrence rate was 32.3%. The meta-analysis estimated significantly higher odds ratios for advanced T categories, than cT1-T2 tumors for OS and DSS (OR = 3.55; 95% CI, 1.93-6.52, and OR = 3.73; 95% CI, 2.00-6.97, respectively). In conclusion, locally advanced tumors were associated with poor prognosis. Poor outcomes mostly occurred due to local recurrence. |
