The Role of Cytokines in Cholesterol Accumulation in Cells and Atherosclerosis Progression.

Autor: Markin AM; Petrovsky National Research Center of Surgery, 119991 Moscow, Russia.; Peoples' Friendship University of Russia (RUDN University), 117198 Moscow, Russia., Markina YV; Petrovsky National Research Center of Surgery, 119991 Moscow, Russia., Bogatyreva AI; Petrovsky National Research Center of Surgery, 119991 Moscow, Russia., Tolstik TV; Petrovsky National Research Center of Surgery, 119991 Moscow, Russia., Chakal DA; Petrovsky National Research Center of Surgery, 119991 Moscow, Russia., Breshenkov DG; Petrovsky National Research Center of Surgery, 119991 Moscow, Russia., Charchyan ER; Petrovsky National Research Center of Surgery, 119991 Moscow, Russia.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2023 Mar 29; Vol. 24 (7). Date of Electronic Publication: 2023 Mar 29.
DOI: 10.3390/ijms24076426
Abstrakt: Atherosclerosis is the most common cardiovascular disease and is the number one cause of death worldwide. Today, atherosclerosis is a multifactorial chronic inflammatory disease with an autoimmune component, accompanied by the accumulation of cholesterol in the vessel wall and the formation of atherosclerotic plaques, endothelial dysfunction, and chronic inflammation. In the process of accumulation of atherogenic lipids, cells of the immune system, such as monocytes, macrophages, dendritic cells, etc., play an important role, producing and/or activating the production of various cytokines-interferons, interleukins, chemokines. In this review, we have tried to summarize the most important cytokines involved in the processes of atherogenesis.
Databáze: MEDLINE
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