Hydrogel-Inducing Graphene-Oxide-Derived Core-Shell Fiber Composite for Antibacterial Wound Dressing.

Autor: Kan Y; Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, bld. 1, 121205 Moscow, Russia., Bondareva JV; Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, bld. 1, 121205 Moscow, Russia., Statnik ES; Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, bld. 1, 121205 Moscow, Russia., Koudan EV; Center for Biomedical Engineering, National University of Science and Technology 'MISIS', Leninskiy pr. 4, 119049 Moscow, Russia., Ippolitov EV; Department of Microbiology, Virology, Immunology, A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Delegatskaya St. 20, 127473 Moscow, Russia., Podporin MS; Department of Microbiology, Virology, Immunology, A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Delegatskaya St. 20, 127473 Moscow, Russia., Kovaleva PA; Center for Biomedical Engineering, National University of Science and Technology 'MISIS', Leninskiy pr. 4, 119049 Moscow, Russia., Kapaev RR; Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, bld. 1, 121205 Moscow, Russia.; Department of Chemistry and BINA-BIU Center for Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan 5290002, Israel., Gordeeva AM; Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, bld. 1, 121205 Moscow, Russia., Cvjetinovic J; Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, bld. 1, 121205 Moscow, Russia., Gorin DA; Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, bld. 1, 121205 Moscow, Russia., Evlashin SA; Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, bld. 1, 121205 Moscow, Russia., Salimon AI; Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, bld. 1, 121205 Moscow, Russia.; Center for Biomedical Engineering, National University of Science and Technology 'MISIS', Leninskiy pr. 4, 119049 Moscow, Russia., Senatov FS; Center for Biomedical Engineering, National University of Science and Technology 'MISIS', Leninskiy pr. 4, 119049 Moscow, Russia., Korsunsky AM; Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, bld. 1, 121205 Moscow, Russia.; Multi-Beam Laboratory for Engineering Microscopy, Department of Engineering Science, University of Oxford, Parks Road, Oxford OX1 3PJ, UK.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2023 Mar 26; Vol. 24 (7). Date of Electronic Publication: 2023 Mar 26.
DOI: 10.3390/ijms24076255
Abstrakt: The study reveals the polymer-crosslinker interactions and functionality of hydrophilic nanofibers for antibacterial wound coatings. Coaxial electrospinning leverages a drug encapsulation protocol for a core-shell fiber composite with a core derived from polyvinyl alcohol and polyethylene glycol with amorphous silica (PVA-PEG-SiO 2 ), and a shell originating from polyvinyl alcohol and graphene oxide (PVA-GO). Crosslinking with GO and SiO 2 initiates the hydrogel transition for the fiber composite upon contact with moisture, which aims to optimize the drug release. The effect of hydrogel-inducing additives on the drug kinetics is evaluated in the case of chlorhexidine digluconate (CHX) encapsulation in the core of core-shell fiber composite PVA-PEG-SiO 2 -1x-CHX@PVA-GO. The release rate is assessed with the zero, first-order, Higuchi, and Korsmeyer-Peppas kinetic models, where the inclusion of crosslinking silica provides a longer degradation and release rate. CHX medicated core-shell composite provides sustainable antibacterial activity against Staphylococcus aureus .
Databáze: MEDLINE
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