The Prognostic Value of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio for Small Renal Cell Carcinomas after Image-Guided Cryoablation or Radio-Frequency Ablation.

Autor: Asif A; Royal Surrey NHS Foundation Trust, Surrey GU2 7XX, UK.; Division of Surgery and Interventional Science, University College London, London WC1E 6BT, UK., Chan VW; Division of Surgery and Interventional Science, University College London, London WC1E 6BT, UK.; Leeds Institute of Medical Research, University of Leeds, Leeds LS2 9JT, UK.; Royal Derby Hospital, University Hospitals of Derby and Burton NHS Foundation Trust, Derby DE22 3NE, UK., Osman FH; School of Medicine, Faculty of Medicine and Health, University of Leeds, Leeds LS2 9JT, UK., Koe JS; Chesterfield Royal Hospital NHS Foundation Trust, Chesterfield S44 5BL, UK., Ng A; Division of Surgery and Interventional Science, University College London, London WC1E 6BT, UK.; Royal Free London NHS Foundation Trust, London NW3 2QG, UK., Burton OE; School of Medical Education, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE1 7RU, UK., Cartledge J; Department of Urology, St. James's University Hospital, Leeds LS9 7TF, UK., Kimuli M; Department of Urology, St. James's University Hospital, Leeds LS9 7TF, UK., Vasudev N; Department of Medical Oncology, St. James's University Hospital, Leeds LS9 7TF, UK., Ralph C; Department of Medical Oncology, St. James's University Hospital, Leeds LS9 7TF, UK., Jagdev S; Department of Medical Oncology, St. James's University Hospital, Leeds LS9 7TF, UK., Bhattarai S; Department of Pathology, St. James's University Hospital, Leeds LS9 7TF, UK., Smith J; Department of Diagnostic and Interventional Radiology, Institute of Oncology, Leeds Teaching Hospitals Trust, St. James's University Hospital, Leeds LS9 7TF, UK., Lenton J; Department of Diagnostic and Interventional Radiology, Institute of Oncology, Leeds Teaching Hospitals Trust, St. James's University Hospital, Leeds LS9 7TF, UK., Wah TM; Leeds Institute of Medical Research, University of Leeds, Leeds LS2 9JT, UK.; Department of Diagnostic and Interventional Radiology, Institute of Oncology, Leeds Teaching Hospitals Trust, St. James's University Hospital, Leeds LS9 7TF, UK.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2023 Apr 06; Vol. 15 (7). Date of Electronic Publication: 2023 Apr 06.
DOI: 10.3390/cancers15072187
Abstrakt: There is a lack of cheap and effective biomarkers for the prediction of renal cancer outcomes post-image-guided ablation. This is a retrospective study of patients with localised small renal cell cancer (T1a or T1b) undergoing cryoablation or radiofrequency ablation (RFA) at our institution from 2003 to 2016. A total of 203 patients were included in the analysis. In the multivariable analysis, patients with raised neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) pre-operatively, post-operatively and peri-operatively are associated with significantly worsened cancer-specific survival, overall survival and metastasis-free survival. Furthermore, an increased PLR pre-operatively is also associated with increased odds of a larger than 25% drop in renal function post-operatively. In conclusion, NLR and PLR are effective prognostic factors in predicting oncological outcomes and peri-operative outcomes; however, larger external datasets should be used to validate the findings prior to clinical application.
Databáze: MEDLINE
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