MR Vascular Fingerprinting with Hybrid Gradient-Spin Echo Dynamic Susceptibility Contrast MRI for Characterization of Microvasculature in Gliomas.

Autor: Venugopal K; Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.; Erasmus MC Cancer Institute, Erasmus MC, 3015 GD Rotterdam, The Netherlands., Arzanforoosh F; Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.; Erasmus MC Cancer Institute, Erasmus MC, 3015 GD Rotterdam, The Netherlands., van Dorth D; C. J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Smits M; Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.; Erasmus MC Cancer Institute, Erasmus MC, 3015 GD Rotterdam, The Netherlands., van Osch MJP; C. J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Hernandez-Tamames JA; Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.; Erasmus MC Cancer Institute, Erasmus MC, 3015 GD Rotterdam, The Netherlands.; Department of Medical Imaging, Faculty of Applied Physics, Delft University of Technology, 2628 CD Delft, The Netherlands., Warnert EAH; Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.; Erasmus MC Cancer Institute, Erasmus MC, 3015 GD Rotterdam, The Netherlands., Poot DHJ; Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.; Erasmus MC Cancer Institute, Erasmus MC, 3015 GD Rotterdam, The Netherlands.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2023 Apr 06; Vol. 15 (7). Date of Electronic Publication: 2023 Apr 06.
DOI: 10.3390/cancers15072180
Abstrakt: Characterization of tumor microvasculature is important in tumor assessment and studying treatment response. This is possible by acquiring vascular biomarkers with magnetic resonance imaging (MRI) based on dynamic susceptibility contrast (DSC). We propose magnetic resonance vascular fingerprinting (MRVF) for hybrid echo planar imaging (HEPI) acquired during the first passage of the contrast agent (CA). The proposed approach was evaluated in patients with gliomas, and we simultaneously estimated vessel radius and relative cerebral blood volume. These parameters were also compared to the respective values estimated using the previously introduced vessel size imaging (VSI) technique. The results of both methods were found to be consistent. MRVF was also found to be robust to noise in the estimation of the parameters. DSC-HEPI-based MRVF provides characterization of microvasculature in gliomas with a short acquisition time and can be further improved in several ways to increase our understanding of tumor physiology.
Databáze: MEDLINE
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