Dynamic synchronization between hippocampal representations and stepping.

Autor: Joshi A; Howard Hughes Medical Institute, University of California, San Francisco, CA, USA. abhilasha.joshi@ucsf.edu.; Departments of Physiology and Psychiatry, University of California, San Francisco, CA, USA. abhilasha.joshi@ucsf.edu., Denovellis EL; Howard Hughes Medical Institute, University of California, San Francisco, CA, USA.; Departments of Physiology and Psychiatry, University of California, San Francisco, CA, USA., Mankili A; Howard Hughes Medical Institute, University of California, San Francisco, CA, USA.; Departments of Physiology and Psychiatry, University of California, San Francisco, CA, USA., Meneksedag Y; Howard Hughes Medical Institute, University of California, San Francisco, CA, USA.; Faculty of Medicine, Hacettepe University, Ankara, Turkey., Davidson TJ; Howard Hughes Medical Institute, University of California, San Francisco, CA, USA., Gillespie AK; Departments of Physiology and Psychiatry, University of California, San Francisco, CA, USA.; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, CA, USA., Guidera JA; Departments of Physiology and Psychiatry, University of California, San Francisco, CA, USA., Roumis D; Departments of Physiology and Psychiatry, University of California, San Francisco, CA, USA., Frank LM; Howard Hughes Medical Institute, University of California, San Francisco, CA, USA. loren.frank@ucsf.edu.; Departments of Physiology and Psychiatry, University of California, San Francisco, CA, USA. loren.frank@ucsf.edu.; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, CA, USA. loren.frank@ucsf.edu.
Jazyk: angličtina
Zdroj: Nature [Nature] 2023 May; Vol. 617 (7959), pp. 125-131. Date of Electronic Publication: 2023 Apr 12.
DOI: 10.1038/s41586-023-05928-6
Abstrakt: The hippocampus is a mammalian brain structure that expresses spatial representations 1 and is crucial for navigation 2,3 . Navigation, in turn, intricately depends on locomotion; however, current accounts suggest a dissociation between hippocampal spatial representations and the details of locomotor processes. Specifically, the hippocampus is thought to represent mainly higher-order cognitive and locomotor variables such as position, speed and direction of movement 4-7 , whereas the limb movements that propel the animal can be computed and represented primarily in subcortical circuits, including the spinal cord, brainstem and cerebellum 8-11 . Whether hippocampal representations are actually decoupled from the detailed structure of locomotor processes remains unknown. To address this question, here we simultaneously monitored hippocampal spatial representations and ongoing limb movements underlying locomotion at fast timescales. We found that the forelimb stepping cycle in freely behaving rats is rhythmic and peaks at around 8 Hz during movement, matching the approximately 8 Hz modulation of hippocampal activity and spatial representations during locomotion 12 . We also discovered precisely timed coordination between the time at which the forelimbs touch the ground ('plant' times of the stepping cycle) and the hippocampal representation of space. Notably, plant times coincide with hippocampal representations that are closest to the actual position of the nose of the rat, whereas between these plant times, the hippocampal representation progresses towards possible future locations. This synchronization was specifically detectable when rats approached spatial decisions. Together, our results reveal a profound and dynamic coordination on a timescale of tens of milliseconds between central cognitive representations and peripheral motor processes. This coordination engages and disengages rapidly in association with cognitive demands and is well suited to support rapid information exchange between cognitive and sensory-motor circuits.
(© 2023. The Author(s).)
Databáze: MEDLINE
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