Preliminary study of the interactive effects of THC and ethanol on self-reported ability and simulated driving, subjective effects, and cardiovascular responses.

Autor: Schnakenberg Martin AM; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; VA Connecticut Healthcare System, 950 Campbell Ave, West Haven, CT, 05615, USA., Flynn LT; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; VA Connecticut Healthcare System, 950 Campbell Ave, West Haven, CT, 05615, USA., Sefik E; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; VA Connecticut Healthcare System, 950 Campbell Ave, West Haven, CT, 05615, USA., Luddy C; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; VA Connecticut Healthcare System, 950 Campbell Ave, West Haven, CT, 05615, USA., Cortes-Briones J; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; VA Connecticut Healthcare System, 950 Campbell Ave, West Haven, CT, 05615, USA., Skosnik PD; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; VA Connecticut Healthcare System, 950 Campbell Ave, West Haven, CT, 05615, USA., Pittman B; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA., Ranganathan M; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; VA Connecticut Healthcare System, 950 Campbell Ave, West Haven, CT, 05615, USA., D'Souza DC; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. deepak.dsouza@yale.edu.; VA Connecticut Healthcare System, 950 Campbell Ave, West Haven, CT, 05615, USA. deepak.dsouza@yale.edu.
Jazyk: angličtina
Zdroj: Psychopharmacology [Psychopharmacology (Berl)] 2023 Jun; Vol. 240 (6), pp. 1235-1246. Date of Electronic Publication: 2023 Apr 12.
DOI: 10.1007/s00213-023-06356-0
Abstrakt: Rationale: Drug- and alcohol-related motor vehicle accidents are a leading cause of morbidity and mortality worldwide. Compared to alcohol, less is known about the effects of cannabis on driving and even less about their combined effects.
Objective: To characterize the combined and separate effects of ethanol and tetrahydrocannabinol (THC) on perceived ability to drive, subjective effects, and simulated driving.
Methods: In a within-subject (crossover), randomized, placebo-controlled, double-blind, 2 × 2 design, the effects of oral THC (10 mg [dronabinol] or placebo) and low-dose intravenous ethanol (clamped at BAC 0.04% or placebo) on perceived ability to drive, simulated driving (standard deviation of lateral position [SDLP]), subjective effects (e.g., "high"), and physiological effects (e.g., heart rate) were studied in healthy humans (n = 18).
Results: Subjects reported reductions in perceived ability to drive (THC < ethanol < combination) which persisted for ~ 6 h (placebo = ethanol, THC < combination). Ethanol and THC produced synergistic effects on heart rate, significant differences compared to either drug alone on perceived ability to drive and feeling states of intoxication (e.g., high), as well increases in SDLP compared to placebo.
Conclusions: Perceived ability to drive is reduced under the influence of THC against the backdrop of blood alcohol levels that are below the legal limit. People should be aware that the effects of oral THC on driving may persist for up to six hours from administration. Findings are relevant to the increasingly common practice of combining alcohol and cannabinoids and the effects on driving.
(© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)
Databáze: MEDLINE
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