The Fischer protocol for assisted reproductive technology treatment: Real-world data experience comparing elective single versus double embryo transfer with or without comprehensive chromosome screening.

Autor: Baukloh V; MVZ Fertility Center Hamburg, Speersort 4, 20095, Hamburg, Germany., Figueira RCS; ANDROFERT, Andrology and Human Reproduction Clinic, Av. Dr. Heitor Penteado, 1464, Campinas-SP, 13075-460, Brazil., Bento FC; ANDROFERT, Andrology and Human Reproduction Clinic, Av. Dr. Heitor Penteado, 1464, Campinas-SP, 13075-460, Brazil., Nakano FY; ANDROFERT, Andrology and Human Reproduction Clinic, Av. Dr. Heitor Penteado, 1464, Campinas-SP, 13075-460, Brazil., Zabaglia SFC; ANDROFERT, Andrology and Human Reproduction Clinic, Av. Dr. Heitor Penteado, 1464, Campinas-SP, 13075-460, Brazil., Esteves SC; ANDROFERT, Andrology and Human Reproduction Clinic, Av. Dr. Heitor Penteado, 1464, Campinas-SP, 13075-460, Brazil., Fischer R; MVZ Fertility Center Hamburg, Speersort 4, 20095, Hamburg, Germany. Electronic address: robert.fischer@amedes-group.com.
Jazyk: angličtina
Zdroj: Best practice & research. Clinical obstetrics & gynaecology [Best Pract Res Clin Obstet Gynaecol] 2023 Jun; Vol. 88, pp. 102325. Date of Electronic Publication: 2023 Feb 27.
DOI: 10.1016/j.bpobgyn.2023.102325
Abstrakt: High rates of multiple implantation after assisted reproductive technology (ART) treatment represent one of the major problems for both mothers and their fetuses. Given the availability of techniques intended to identify embryos with the highest chance for development to term, such as comprehensive chromosome screening (CCS) and blastocyst transfer, the decision on the number of embryos to transfer deserves careful consideration. This report presents real-life data from two clinics using the Fischer protocol for cycle programming in patients undergoing ART. Our data indicate that ovarian stimulation using the Fischer protocol provides consistent and optimal ART outcomes in centers following strict quality management standards. However, high multiple implantation rates were observed in fresh and frozen transfer cycles after transferring two embryos - even in patients aged over 39 years. The live birth rates after CCS were superior to those using untested embryos. These findings were held for the three age groups irrespective of the CCS culture day (D1 = PN stages, or D5 = blastocysts). Our results support a single embryo transfer policy, particularly in women under 34 years of age with favorable conditions during ART treatment, i.e., a high number of available fertilized oocytes.
Competing Interests: Declaration of competing interest S.C.E. declares receipt of unrestricted research grants from Merck and lecture fees from Merck, and Med.E.A. R.F. declares receipt of payment for lectures from Merck and Med.E.A. The remaining authors have nothing to disclose.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: