Role of long non-coding RNAs in pancreatic cancer pathogenesis and treatment resistance- A review.

Autor: Al-Noshokaty TM; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt., Mansour A; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt., Abdelhamid R; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt., Abdellatif N; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt., Alaaeldien A; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt., Reda T; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt., Abdelmaksoud NM; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt., Doghish AS; Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr, Cairo 11829, Egypt; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr, Cairo 11231, Egypt. Electronic address: ahmed_doghish@azhar.edu.eg., Abulsoud AI; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr, Cairo 11231, Egypt. Electronic address: abulsoudahmed@azhar.edu.eg., Elshaer SS; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr, Cairo, Egypt.
Jazyk: angličtina
Zdroj: Pathology, research and practice [Pathol Res Pract] 2023 May; Vol. 245, pp. 154438. Date of Electronic Publication: 2023 Apr 06.
DOI: 10.1016/j.prp.2023.154438
Abstrakt: Pancreatic cancer (PC) is one of the deadliest cancers associated with poor prognosis. The lack of reliable means of early cancer detection contributes to this disease's dismal prognosis. Long non-coding RNAs (LncRNAs) are protein-free RNAs produced by genome transcription; they play critical roles in gene expression regulation, epigenetic modification, cell proliferation, differentiation, and reproduction. Recent research has shown that lncRNAs play important regulatory roles in PC behaviors, in addition to their recently found functions. Several in-depth investigations have shown that lncRNAs are strongly linked to PC development and progression. Here, we discuss how lncRNAs, which are often overlooked, play many roles as regulators in the molecular mechanism underlying PC. This review also discusses the involved LncRNAs in PC pathogenesis and treatment resistance.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
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