Dual-Function Hydrogel Dressings with a Dynamic Exchange of Iron Ions and an Antibiotic Drug for Treatment of Infected Wounds.

Autor:	Pilipenko I; SCAMT Institute, ITMO University, Saint Petersburg 191002, Russian Federation., Murzova A; SCAMT Institute, ITMO University, Saint Petersburg 191002, Russian Federation., Savin A; SCAMT Institute, ITMO University, Saint Petersburg 191002, Russian Federation., Mohamed AA; SCAMT Institute, ITMO University, Saint Petersburg 191002, Russian Federation., Vladimirova E; Department of General Pathology and Pathophysiology, Institute of Experimental Medicine, Saint Petersburg 197376, Russian Federation., Koshel E; SCAMT Institute, ITMO University, Saint Petersburg 191002, Russian Federation., Shamova O; Department of General Pathology and Pathophysiology, Institute of Experimental Medicine, Saint Petersburg 197376, Russian Federation., Kumacheva E; Department of Chemistry, University of Toronto, Toronto, Ontario M5S 2Y2, Canada.; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada.; Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College St, Toronto, Ontario M5S 3E5, Canada.
Jazyk:	angličtina
Zdroj:	ACS applied bio materials [ACS Appl Bio Mater] 2023 May 15; Vol. 6 (5), pp. 1896-1905. Date of Electronic Publication: 2023 Apr 12.
DOI:	10.1021/acsabm.3c00124
Abstrakt:	Bacterial infection is a major problem with diabetic wounds that may result in nonhealing chronic ulcers. Here, we report an approach to antibacterial hydrogel dressings for enhanced treatment of infected skin wounds. A fibrous hydrogel was derived from cellulose nanocrystals that were modified with dopamine and cross-linked with gelatin. The hydrogel was loaded with gentamicin, an antibiotic drug. Enhanced antibacterial hydrogel performance resulted from (i) a highly specific sequestration of Fe 3+ ions (much needed by bacteria) from the wound exudate and (ii) a dynamic exchange between gentamicin released from the hydrogel and Fe 3+ ions withdrawn from the wound exudate. Such exchange was possible due to the high value of the binding constant of Fe 3+ ions to dopamine. The hydrogel did not affect the metabolic activity of skin-related cells and showed enhanced antibacterial performance against common wound pathogens such as S. aureus and P. aeruginosa . Furthermore, it promoted healing of infected diabetic wounds due to a synergistic antibacterial effect providing the dynamic exchange between Fe 3+ ions and gentamicin. This work provides a strategy for the design of dual-function wound dressings, with both starving and killing bacteria and enhanced wound healing performance.
Databáze:	MEDLINE
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