Modafinil Improves Autism-like Behavior in Rats by Reducing Neuroinflammation.

Autor: Bagcioglu E; Department of Clinical Psychology, Ruhr University, Bochum, Germany. ermanbagcioglu@yahoo.com., Solmaz V; Department of Neurophysiology, Cologne University, Cologne, Germany., Erbas O; Department of Physiology, Istanbul Bilim University School of Medicine, Istanbul, Turkey., Özkul B; Department of Radiology, Istanbul Atlas University, Istanbul, Turkey., Çakar B; Department of Histology and Embryology, Faculty of Medicine, Ege University, Izmir, Turkey., Uyanikgil Y; Department of Histology and Embryology, Faculty of Medicine, Ege University, Izmir, Turkey., Söğüt İ; Department of Biochemistry, Demiroğlu Bilim University, Istanbul, Turkey.
Jazyk: angličtina
Zdroj: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology [J Neuroimmune Pharmacol] 2023 Jun; Vol. 18 (1-2), pp. 9-23. Date of Electronic Publication: 2023 Apr 12.
DOI: 10.1007/s11481-023-10061-2
Abstrakt: To evaluate the ameliorating effect of Modafinil on neuroinflammation, behavioral, and histopathological alterations in rats induced by propionic acid (PPA). Thirty male Wistar rats were used in the study, divided into 3 groups of ten subjects. One group served as a control, the subjects in the other two were given 250 mg/kg/day of PPA by intraperitoneal injection over the course of 5 days to induce autism. The experimental design was as follows: Group 1: Normal control (orally-fed control, n = 10); Group 2 (PPA + saline, n = 10): PPA and 1 ml/kg/day % 0.9 NaCl saline via oral gavage; Group 3 (PPA + Modafinil, n = 10) PPA and 30 mg/kg/day Modafinil (Modiodal tablets 100 mg, Cephalon) via oral gavage. All of the groups were investigated for behavioral, biochemical, and histological abnormality. Autism-like behaviors were reduced significantly in the rats treated with PPA. TNF-α, Nerve Growth Factor (NGF), IL-17, IL-2, and NF-KB levels as well as MDA levels and lactate were significantly higher in those treated with PPA compared to the control group. Using immunohistochemical methods, the number of neurons and GFAP immunoreactivity was significantly altered in PPA-treated rats compared to the control. Using Magnetic Resonance Spectroscopy (MRS), we found that lactate levels were significantly higher in the PPA-treated rats, while creatinine levels were significantly decreased. In the rats administered with Modafinil, behavior, neuroinflammation, and histopathological changes brought about by PPA were significantly reversed. Our results demonstrate the potential role of Modafinil in ameliorating PPA-induced neuroinflammation in rats.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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